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Cutoff values of surrogate measures of insulin resistance for metabolic syndrome in Korean non-diabetic adults.

Authors
Lee, S; Choi, S; Kim, HJ; Chung, YS; Lee, KW; Lee, HC; Huh, KB; Kim, DJ
Citation
Journal of Korean medical science, 21(4):695-700, 2006
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
We investigated the cutoff values of surrogate of insulin resistance for diagnosing metabolic syndrome in Korean adults. The data from 976 non-diabetic individuals (484 men and 492 women) aged 30-79 yr were analyzed. We determined the odds ratios for the prevalence of metabolic syndrome according to the quartiles of fasting insulin, homeostasis model for insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI) as independent variables, while adjusting for age, sex, and body mass index. The cutoff values of fasting insulin, HOMA-IR, and QUICKI were estimated by the areas under the receiver-operating characteristic (ROC) curves. The cutoff points for defining insulin resistance are a fasting insulin level of 12.94 microU/mL, HOMA-IR=3.04 as the 75th percentile value, and QUICKI=0.32 as the 25th percentile value. Compared with the lowest quartile, the adjusted odds ratios for the prevalence of metabolic syndrome in the highest quartiles of fasting insulin, HOMA-IR, and QUICKI were 1.95 (1.26-3.01), 2.27 (1.45-3.56), and 2.27 (1.45-3.56), respectively. The respective cutoff values for fasting serum insulin, HOMA-IR, and QUIC-KI by ROC analysis were 10.57 microU/mL (sensitivity 58.5%, specificity 66.8%), 2.34 (sensitivity 62.8%, specificity 65.7%), and 0.33 (sensitivity 61.2%, specificity 66.8%). Fasting insulin, HOMA-IR, and QUICKI can be used as surrogate measures of insulin resistance in Korean non-diabetic adults.
MeSH terms
AdultAgedBlood Glucose/analysisBlood Pressure/physiologyCholesterol/bloodCholesterol, HDL/bloodDiabetes Mellitus/bloodDiabetes Mellitus/physiopathologyFasting/bloodFemaleHumansInsulin/blood*Insulin Resistance*KoreaMaleMetabolic Syndrome X/blood*Metabolic Syndrome X/diagnosisMetabolic Syndrome X/physiopathologyMiddle AgedMultivariate AnalysisPredictive Value of TestsTriglycerides/blood
DOI
10.3346/jkms.2006.21.4.695
PMID
16891815
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
김, 혜진정, 윤석이, 관우김, 대중
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