123 299

Cited 4 times in

Changes of serum cytokines after the long term immunotherapy with Japanese hop pollen extracts.

Authors
Ye, YM; Lee, SK; Kim, SH; Nahm, DH; Suh, CH; Park, HS
Citation
Journal of Korean medical science, 21(5):805-810, 2006
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Japanese hop (Hop J) pollen has been considered as one of the major causative pollen allergens in the autumn season. We developed a new Hop J immunotherapy extract in collaboration with Allergopharma (Reinbeck, Germany) and investigated immunologic mechanisms during 3 yr immunotherapy. Twenty patients (13 asthma with rhinitis and 7 hay fever) were enrolled from Ajou University Hospital. Sera were collected before, 1 yr, and 3 yr after the immunotherapy. Changes of serum specific IgE, IgG1, and IgG4 levels to Hop J pollen extracts and serum IL-10, IL-12, TGF-beta1 and soluble CD23 levels were monitored by ELISA. Skin reactivity and airway hyper-responsiveness to methacholine were improved during the study period. Specific IgG1 increased at 1 yr then decreased again at 3 yr, and specific IgG4 levels increased progressively (p<0.05, respectively), whereas total and specific IgE levels showed variable responses with no statistical significance. IL-10, TGF-beta1 and soluble CD23 level began to decrease during first year and then further decreased during next two years with statistical significances. (p<0.05, respectively). In conclusion, these findings suggested the favorable effect of long term immunotherapy with Hop J pollen extracts can be explained by lowered IgE affinity and generation of specific IgG4, which may be mediated by IL-10 and TGF-beta1.
MeSH terms
Bronchial Hyperreactivity/etiologyCytokines/blood*Desensitization, Immunologic*HumansImmunoglobulin E/bloodImmunoglobulin G/bloodInterleukin-10/bloodPoaceae/immunology*Pollen/immunology*Receptors, IgE/bloodTransforming Growth Factor beta/blood
DOI
10.3346/jkms.2006.21.5.805
PMID
17043410
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
예영민김승현남동호서창희박해심
Full Text Link
Files in This Item:
jkms-21-805-810.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse