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Prevention of propofol-induced pain in children: combination of alfentanil and lidocaine vs alfentanil or lidocaine alone.

Authors
Kwak, HJ; Min, SK; Kim, JS; Kim, JY
Citation
British journal of anaesthesia, 103(3):410-412, 2009
Journal Title
British journal of anaesthesia
ISSN
0007-09121471-6771
Abstract
BACKGROUND: Pain from a propofol injection is a common side-effect in paediatric patients. This prospective, randomized, double-blind study evaluated the efficacy of a combined pretreatment of alfentanil with lidocaine on the incidence and severity of propofol injection pain in children. METHODS: After obtaining parental consent, 120 paediatric patients were allocated randomly into one of the three groups (n=40, in each). The patients in the alfentanil group received alfentanil 15 microg kg(-1) 90 s before the propofol injection. The patients in the lidocaine group received propofol 3 mg kg(-1) premixed with lidocaine 0.1% over a 15 s period. The patients in the combination group received both alfentanil and lidocaine. RESULTS: The incidence of propofol injection pain (severity 2 or more) in the combination group (2.6%) was significantly lower than that in the alfentanil and lidocaine groups (30% and 38.5%, respectively) (P=0.001 and <0.001, respectively). No patient in the combination group complained of moderate or severe pain from propofol injection. CONCLUSIONS: Our study demonstrated that the combination treatment of two different analgesic modalities, alfentanil and lidocaine, could prevent the moderate and severe pain on propofol injection, and reduce the incidence of mild pain compared with each drug alone.
MeSH terms
Alfentanil/therapeutic use*Analgesics, Opioid/therapeutic useAnesthetics, Intravenous/adverse effects*Anesthetics, Local/therapeutic useChildChild, PreschoolDouble-Blind MethodDrug Therapy, CombinationFemaleHumansInjections, Intravenous/adverse effectsLidocaine/therapeutic use*MalePain/chemically inducedPain/prevention & control*Propofol/adverse effects*Prospective Studies
DOI
10.1093/bja/aep163
PMID
19542104
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
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