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Cardiac 123I-MIBG scintigraphy in patients with drug induced parkinsonism.

Authors
Lee, PH; Kim, JS; Shin, DH; Yoon, SN; Huh, K
Citation
Journal of neurology, neurosurgery, and psychiatry, 77(3):372-374, 2006
Journal Title
Journal of neurology, neurosurgery, and psychiatry
ISSN
0022-30501468-330X
Abstract
Cardiac sympathetic dysfunction was investigated using 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 20 patients with drug induced parkinsonism (DIP). The mean heart to mediastinum ratio was significantly greater in patients with DIP than in those with Parkinson's disease (mean (SD): 2.07 (0.39) v 1.28 (0.15), p<0.001). MIBG uptake was not different between the DIP patients and controls. Two DIP patients whose MIBG uptake was significantly reduced showed persistent parkinsonism and responded dramatically to levodopa.
MeSH terms
AdultAgedAntipsychotic Agents/toxicity*Calcium Channel Blockers/toxicity*Dopamine Antagonists/toxicity*FemaleHeart/innervationHeart Diseases/chemically induced*Heart Diseases/radionuclide imagingHumansMaleMediastinum/radionuclide imagingMiddle AgedParkinsonian Disorders/chemically induced*Parkinsonian Disorders/radionuclide imagingPrognosisProspective StudiesSympathetic Nervous System/drug effectsSympathetic Nervous System/radionuclide imagingTechnetium Tc 99m Sestamibi/diagnostic use*Tomography, Emission-Computed, Single-Photon*
DOI
10.1136/jnnp.2005.073999
PMID
16103041
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
AJOU Authors
이필휴윤석남허균
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