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The dermal stem cell factor and c-kit are overexpressed in melasma.

Authors
Kang, HY; Hwang, JS; Lee, JY; Ahn, JH; Kim, JY; Lee, ES; Kang, WH
Citation
The British journal of dermatology, 154(6):1094-1099, 2006
Journal Title
The British journal of dermatology
ISSN
0007-09631365-2133
Abstract
BACKGROUND: The pathogenesis of melasma has not yet been clearly demonstrated. We tried to determine whether the stem cell factor (SCF) and its receptor c-kit are involved in the mechanism of hyperpigmentation of melasma because this factor is highly implicated in the stimulation of melanocyte function in vitro and in vivo. OBJECTIVES: The present study was conducted to investigate the expression of SCF and c-kit on the lesions of melasma compared with nonlesional skin. PATIENTS/METHODS: Skin samples were obtained from lesional and nonlesional facial skin of 60 Korean women with melasma. Immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was performed to determine the expression of SCF and c-kit in melasma. RESULTS: The expression of SCF was significantly increased at the lesional dermis compared with nonlesional dermis. However, there was no significant difference in the expression of SCF in lesional and nonlesional epidermis. The expression of c-kit was significantly increased at lesional epidermis compared with nonlesional skin. RT-PCR of SCF and c-kit mRNAs demonstrated increased expression of both types of transcripts in the lesional skin compared with nonlesional skin. CONCLUSIONS: These results suggest that the increased expression of SCF in the dermis and of c-kit in the epidermis play an important role in the mechanism of hyperpigmentation in melasma.
MeSH terms
AdultFibroblasts/pathologyHumansMelanosis/metabolism*Melanosis/pathologyProto-Oncogene Proteins c-kit/biosynthesisProto-Oncogene Proteins c-kit/geneticsProto-Oncogene Proteins c-kit/metabolism*RNA, Messenger/geneticsReverse Transcriptase Polymerase Chain Reaction/methodsSkin/metabolism*Skin/pathologyStem Cell Factor/biosynthesisStem Cell Factor/geneticsStem Cell Factor/metabolism*Up-Regulation
DOI
10.1111/j.1365-2133.2006.07179.x
PMID
16704639
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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