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Reproducibility of hepatic MR elastography across field strengths, pulse sequences, scan intervals, and readers

Kim, HJ | Kim, B  | Yu, HJ | Huh, J  | Lee, JH  | Lee, SS | Kim, KW | Kim, JK
Abdominal radiology (New York), 45(1). : 107-115, 2020
Journal Title
Abdominal radiology (New York)
PURPOSE: To evaluate the reproducibility of hepatic MRE under various combinations of settings of field strength, pulse sequence, scan interval, and reader in non-alcoholic fatty liver disease (NAFLD) patients.

METHODS: Adult NAFLD patients were prospectively enrolled for serial hepatic MRE with 1.5 T using 2D GRE sequence and 3.0 T using 2D SE-EPI sequence on the same day and after 2 weeks, resulting a total of four MRE examinations per patient. Three readers with various levels of background knowledge in MRE technique and liver anatomy measured liver stiffness after a training session. Linear regression, Bland-Altman analysis, within-subject coefficient of variation, and reproducibility coefficient (RDC) were used to determine reproducibility of hepatic MRE measurement.

RESULTS: Twenty patients completed the MRE sessions. Liver stiffness through MRE showed pooled RDC of 26% (upper 95% CI 30.6%) and corresponding limits of agreement (LOA) within 0.55 kPa across field strengths, MRE sequences, and 2-week interscan interval in three readers. Small mean biases and narrow LOA were observed among readers (0.05-0.19 kPa ± 0.53).

CONCLUSION: The magnitude of change across combinations of scan parameters is within acceptable clinical range, rendering liver stiffness through MRE a reproducible quantitative imaging biomarker. A lower reproducibility was observed for measurements under different field strengths/MRE sequences at a longer (2 weeks) interscan interval. Operators should be trained to acquire region of interest consistently in repeat examinations.


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Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Ajou Authors
김, 보현  |  김, 재근  |  이, 제희  |  허, 지미
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