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Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas.

Authors
Kim, SH; Kim, JW; Kim, YT; Kim, JH; Yoon, BS; Ryu, HS
Citation
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 95(3):272-277, 2006
Journal Title
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN
0020-72921879-3479
Abstract
OBJECTIVES: To evaluate the clinicopathologic prognostic factors of uterine sarcoma, and determine whether overexpression of p53 and mdm-2 proteins correlate with overall survival and prognostic factors. METHODS: Thirty specimens from 43 patients with uterine sarcoma were available for slide review and evaluated by immunohistochemistry at Yonsei and Ajou University Medical Centers for the expression of p53 and mdm-2. RESULTS: Overall survival was found to correlate to histologic type of uterine sarcoma, surgical stage, tumor grade, and mitotic index. Whereas 63% of the sarcomas expressed p53, with a significant correlation to overall survival, 60% expressed mdm-2, with a significant correlation to the mitotic index but not to overall survival. CONCLUSION: Histologic type, surgical stage, tumor grade, mitotic index, and p53 expression were prognostic factors of the overall survival of patients with uterine sarcoma.
MeSH terms
AdultAgedAged, 80 and overFemaleGene Expression/physiologyHumansImmunohistochemistryKoreaMiddle AgedNeoplasm Staging/adverse effects*PrognosisProto-Oncogene Proteins c-mdm2/metabolism*Retrospective StudiesSarcoma/metabolism*Sarcoma/pathologySurvival AnalysisTumor Suppressor Protein p53/metabolism*Up-Regulation/physiologyUterine Neoplasms/metabolism*Uterine Neoplasms/pathology
DOI
10.1016/j.ijgo.2006.03.031
PMID
16930603
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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