Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas.
Kim, SH; Kim, JW; Kim, YT; Kim, JH; Yoon, BS; Ryu, HS
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 95(3):272-277, 2006
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
OBJECTIVES: To evaluate the clinicopathologic prognostic factors of uterine sarcoma, and determine whether overexpression of p53 and mdm-2 proteins correlate with overall survival and prognostic factors.
METHODS: Thirty specimens from 43 patients with uterine sarcoma were available for slide review and evaluated by immunohistochemistry at Yonsei and Ajou University Medical Centers for the expression of p53 and mdm-2.
RESULTS: Overall survival was found to correlate to histologic type of uterine sarcoma, surgical stage, tumor grade, and mitotic index. Whereas 63% of the sarcomas expressed p53, with a significant correlation to overall survival, 60% expressed mdm-2, with a significant correlation to the mitotic index but not to overall survival.
CONCLUSION: Histologic type, surgical stage, tumor grade, mitotic index, and p53 expression were prognostic factors of the overall survival of patients with uterine sarcoma.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :3,595,542
Total Download :1,509,352
Today View :157
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 / FAX : 031-219-5314 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.