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Cancer development in patients with COPD: a retrospective analysis of the National Health Insurance Service-National Sample Cohort in Korea

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dc.contributor.authorAhn, SV-
dc.contributor.authorLee, E-
dc.contributor.authorPark, B-
dc.contributor.authorJung, JH-
dc.contributor.authorPark, JE-
dc.contributor.authorSheen, SS-
dc.contributor.authorPark, KJ-
dc.contributor.authorHwang, SC-
dc.contributor.authorPark, JB-
dc.contributor.authorPark, HS-
dc.contributor.authorPark, JH-
dc.date.accessioned2022-11-29T01:43:25Z-
dc.date.available2022-11-29T01:43:25Z-
dc.date.issued2020-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/22984-
dc.description.abstractBACKGROUND: COPD is a well-known risk factor for lung cancer, independent of smoking behavior. By investigating the retrospective National Health Insurance Service-National Sample Cohort (NHIS-NSC) in Korea, this study attempted to prove the hypothesis that COPD is a risk factor for major cancers developing outside of the lungs. We also aimed to investigate the environmental factors associated with the development of lung cancer in COPD patients. METHODS: This study analyzed data from the NHIS-NSC over a 12-year period. Among the 514,795 subjects in the NHIS-NSC, 16,757 patients who were diagnosed with any cancer from 2002 to 2003 were excluded. This cohort enrolled six arms consisting of never-smokers without COPD (N = 313,553), former smokers without COPD (N = 41,359), smokers without COPD (N = 112,627), never-smokers with COPD (N = 7789), former smokers with COPD (N = 1085), and smokers with COPD (N = 2677). RESULTS: Incident rate of lung cancer per 100,000 person-year was higher according to smoking and COPD (216 in non-COPD and 757 in COPD among never-smokers, 271 in non-COPD and 1266 in COPD among former smokers, 394 in non-COPD and 1560 in COPD among smokers, p < 0.01). Old age, male sex, lower BMI, low exercise level, history of diabetes mellitus, smoking, and COPD were independent factors associated with the development of lung cancer (p < 0.01). Multi-variable analyses showed that COPD, regardless of smoking status, contributed to the development of lung cancer, and colorectal cancer and liver cancer among other major cancers (p < 0.01). CONCLUSION: Our data suggested that COPD was an independent risk factor for the development of lung cancer, and colorectal cancer and liver cancer among other major cancers in the Korean population, regardless of smoking status.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNational Health Programs-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHPulmonary Disease, Chronic Obstructive-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSmoking-
dc.titleCancer development in patients with COPD: a retrospective analysis of the National Health Insurance Service-National Sample Cohort in Korea-
dc.typeArticle-
dc.identifier.pmid32539764-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296952-
dc.subject.keywordCOPD-
dc.subject.keywordCancer-
dc.subject.keywordSmoking-
dc.contributor.affiliatedAuthorPark, B-
dc.contributor.affiliatedAuthorPark, JE-
dc.contributor.affiliatedAuthorSheen, SS-
dc.contributor.affiliatedAuthorPark, KJ-
dc.contributor.affiliatedAuthorHwang, SC-
dc.contributor.affiliatedAuthorPark, JB-
dc.contributor.affiliatedAuthorPark, HS-
dc.contributor.affiliatedAuthorPark, JH-
dc.type.localJournal Papers-
dc.identifier.doi10.1186/s12890-020-01194-8-
dc.citation.titleBMC pulmonary medicine-
dc.citation.volume20-
dc.citation.number1-
dc.citation.date2020-
dc.citation.startPage170-
dc.citation.endPage170-
dc.identifier.bibliographicCitationBMC pulmonary medicine, 20(1). : 170-170, 2020-
dc.identifier.eissn1471-2466-
dc.relation.journalidJ014712466-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biomedical Informatics
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Journal Papers > School of Medicine / Graduate School of Medicine > Occupational & Environmental Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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