Cited 0 times in Scipus Cited Count

Cancer-associated fibroblast-induced resistance to chemotherapy and radiotherapy in gastrointestinal cancers

DC Field Value Language
dc.contributor.authorHam, IH-
dc.contributor.authorLee, D-
dc.contributor.authorHur, H-
dc.date.accessioned2022-12-26T00:39:05Z-
dc.date.available2022-12-26T00:39:05Z-
dc.date.issued2021-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23461-
dc.description.abstractIn the past few decades, the role of cancer-associated fibroblasts (CAFs) in resistance to therapies for gastrointestinal (GI) cancers has emerged. Clinical studies focusing on GI cancers have revealed that the high expression of CAF-related molecules within tumors is significantly correlated with unfavorable therapeutic outcomes; however, the exact mechanisms whereby CAFs enhance resistance to chemotherapy and radiotherapy in GI cancers remain unclear. The cells of origin of CAFs in GI cancers include normal resident fibroblasts, mesenchymal stem cells, endothelial cells, pericytes, and even epithelial cells. CAFs accumulated within GI cancers produce cytokines, chemokines, and growth factors involved in resistance to therapies. CAF-derived exosomes can be engaged in stroma-related resistance to treatments, and several non-coding RNAs, such as miR-92a, miR-106b, CCAL, and H19, are present in CAF-derived exosomes and transferred to GI cancer cells. The CAF-induced desmoplastic reaction interferes with drug delivery to GI cancer cells, evoking resistance to chemotherapy. However, due to the heterogeneity of CAFs in GI cancers, identifying the exact mechanism underlying CAF-induced resistance may be difficult. Recent advancements in single-cell “omics” technologies could offer clues for revealing the specific subtypes and biomarkers related to resistance.-
dc.language.isoen-
dc.titleCancer-associated fibroblast-induced resistance to chemotherapy and radiotherapy in gastrointestinal cancers-
dc.typeArticle-
dc.identifier.pmid33803229-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963167/-
dc.subject.keywordCancer-associated fibroblasts-
dc.subject.keywordChemotherapy-
dc.subject.keywordGastrointestinal cancer-
dc.subject.keywordRadiotherapy-
dc.subject.keywordResistance-
dc.contributor.affiliatedAuthorHam, IH-
dc.contributor.affiliatedAuthorHur, H-
dc.type.localJournal Papers-
dc.identifier.doi10.3390/cancers13051172-
dc.citation.titleCancers-
dc.citation.volume13-
dc.citation.number5-
dc.citation.date2021-
dc.citation.startPage1172-
dc.citation.endPage1172-
dc.identifier.bibliographicCitationCancers, 13(5). : 1172-1172, 2021-
dc.identifier.eissn2072-6694-
dc.relation.journalidJ020726694-
Appears in Collections:
Journal Papers > Research Organization > Inflamm-aging Translational Research Center
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Files in This Item:
33803229.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse