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Cell membrane and nuclear expression of programmed death ligand-1 in prostate needle biopsy tissue in prostate cancer patients undergoing primary radiation therapy

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dc.contributor.authorShim, KH-
dc.contributor.authorKwon, JE-
dc.contributor.authorPark, SG-
dc.contributor.authorChoo, SH-
dc.contributor.authorKim, SJ-
dc.contributor.authorKim, SI-
dc.date.accessioned2023-01-05T03:03:36Z-
dc.date.available2023-01-05T03:03:36Z-
dc.date.issued2021-
dc.identifier.issn1078-1439-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23728-
dc.description.abstractBackground: Programmed death ligand-1 (PD-L1) expression in cancer is often associated with cancer aggressiveness and responsiveness to treatment with PD-1 pathway inhibitors. We conducted a systematic study on the expression of membranous PD-L1 (mPD-L1) and nuclear PD-1-L1 (nPD-L1) in prostate needle biopsy specimens of prostate cancer patients who underwent primary radiotherapy and analyzed the association between PD-L1 expression and clinicopathological characteristics and prognosis of patients. Method: A total of 971 cancer-containing prostate needle biopsy cores from 172 patients were immunohistochemically stained with anti-PD-L1 antibody. The association of PD-L1 expression with Gleason score and tumor volume percentage was evaluated for each biopsy core. Total of 171 patients were divided according to mPD-L1 or nPD-L1 expression, and clinicopathological characteristics were compared between the positive and negative groups. The prognostic significance of mPD-L1, nPD-L1 and common prognostic factors were analyzed in terms of biochemical recurrence. Result: Total of 15% and 46% of biopsy cores were stained positive for mPD-L1 and nPD-L1, respectively. There was a positive correlation between Gleason score and mPD-L1 and a negative correlation between Gleason score and nPD-L1. Between mPD-L1 and nPD-L1, there was no significant correlation. There was intraindividual heterogeneity in PD-L1 expression among different Gleason scores. For mPD-L1, only pretreatment PSA was significantly higher in the positive group than in the negative, but not Gleason score and T stage. For nPD-L1, Gleason score and T stage were significantly higher in the positive group than in the negative. Both mPD-L1 and nPD-L1 expression were not predictive of BCR-free survival in univariate and multivariate analyses. Conclusions: Our results suggest that PD-1 pathway inhibitor may be a potential therapeutic option in high risk prostate cancer patients as early as neoadjuvant setting. The novel discovery of PD-L1 expression in the nucleus of PC should be subjected to further research.-
dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHB7-H1 Antigen-
dc.subject.MESHBiopsy, Needle-
dc.subject.MESHCell Membrane-
dc.subject.MESHCell Nucleus-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProstate-
dc.subject.MESHProstatic Neoplasms-
dc.subject.MESHRetrospective Studies-
dc.titleCell membrane and nuclear expression of programmed death ligand-1 in prostate needle biopsy tissue in prostate cancer patients undergoing primary radiation therapy-
dc.typeArticle-
dc.identifier.pmid33712343-
dc.subject.keywordImmunohistochemistry-
dc.subject.keywordProgrammed death ligand-1-
dc.subject.keywordProstate cancer-
dc.contributor.affiliatedAuthorShim, KH-
dc.contributor.affiliatedAuthorKwon, JE-
dc.contributor.affiliatedAuthorChoo, SH-
dc.contributor.affiliatedAuthorKim, SJ-
dc.contributor.affiliatedAuthorKim, SI-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.urolonc.2021.01.032-
dc.citation.titleUrologic oncology-
dc.citation.volume39-
dc.citation.number5-
dc.citation.date2021-
dc.citation.startPage298.e13-
dc.citation.endPage298.e20-
dc.identifier.bibliographicCitationUrologic oncology, 39(5). : 298.e13-298.e20, 2021-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1873-2496-
dc.relation.journalidJ010781439-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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