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Atypical teratoid/rhabdoid tumors of the central nervous system: imaging and clinical findings in 16 children.

Lee, IH; Yoo, SY; Kim, JH; Eo, H; Kim, OH; Kim, IO; Cheon, JE; Jung, AY; Yoon, BJ
Clinical radiology, 64(3):256-264, 2009
Journal Title
Clinical radiology
AIM: To investigate the imaging and clinical findings of central nervous system (CNS) atypical teratoid/rhabdoid tumours (AT/RTs) in children.

MATERIALS AND METHODS: The computed tomography (CT) and magnetic resonance imaging (MRI) findings and clinical records of 16 children with CNS AT/RTs were retrospectively reviewed. Tumour location, size, composition, enhancement pattern, peritumoural oedema, signal intensity (SI) on MRI and CT attenuation were evaluated.

RESULTS: A total of 17 lesions from 16 patients (median age 2.3 years, age range 0.7-15 years) were included in the evaluation. Tumour location was infratentorial for 11 lesions and supratentorial for six lesions. The mean diameter of the largest dimension for a tumour was 4 cm. The tumour was mainly solid in 65% of cases, and solid and cystic or cystic and solid in 35% of cases. The solid component of the tumours had a homogeneous iso SI (n=15) on T2-weighted MRI images and iso SI (n=14) on T1-weighted images. Moderate to strong enhancement of the solid component was noted in most cases. In spite of a large tumour size, peritumoural oedema was minimal or mild except in four cases. Rapid growth of the tumour was demonstrated in three cases. Seven patients died from tumour progression, with a mean survival time of 8.4 months (range 2-12 months).

CONCLUSION: Although the AT/RTs had non-specific imaging findings, the tumours tended to be large in size, have iso SI on T1 and T2-weighted MR images with prominent enhancement, and relatively mild peritumoural oedema. Rapid growth of the tumour was seen during the follow-up period.
MeSH terms
AdolescentBrain Neoplasms/diagnosis*Brain Neoplasms/pathologyChildChild, PreschoolFemaleHumansImage Interpretation, Computer-Assisted/methodsInfantKoreaMagnetic Resonance Imaging/methodsMaleRetrospective StudiesRhabdoid Tumor/diagnosis*Rhabdoid Tumor/pathologyTomography, X-Ray Computed/methods
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Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
AJOU Authors
김, 옥화
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