143 570

Cited 4 times in

Epithelial apoptosis as a clinical marker in idiopathic interstitial pneumonia.

Authors
Chung, WY; Sun, JS; Park, JH; Lee, HL; Lee, KS; Kim, YS; Sheen, SS; Park, KJ; Hwang, SC; Lee, KB
Citation
Respiratory medicine, 104(11):1722-1728, 2010
Journal Title
Respiratory medicine
ISSN
0954-61111532-3064
Abstract
BACKGROUNDS: Epithelial cell apoptosis plays an important role in the pathogenesis of idiopathic interstitial pneumonia (IIP).



METHODS: Serum levels of caspase-cleaved cytokeratin-18 (M30) were measured in 55 patients with IIP and 34 healthy controls using enzyme-linked immunosorbent assays. The IIP cases included usual interstitial pneumonia (UIP; n = 30), nonspecific interstitial pneumonia (NSIP; n = 15), and cryptogenic organizing pneumonia (COP; n = 10). The radiological scoring was performed based on high-resolution computed tomography (HRCT) findings.



RESULTS: Patients with IIP had higher serum M30 levels than did the control group (178.6 ± 91.5 vs. 113.7 ± 46.8 U/L, p < 0.05). Among IIP patients, COP patients had higher serum M30 levels than did UIP or NSIP patients (264.9 ± 132.7, 139.2 ± 49.7, and 201.2 ± 81.1 U/L, respectively; COP vs. UIP, p < 0.01). Serum M30 levels were negatively correlated with forced vital capacity (FVC; r(s) = -0.31), percent-predicted FVC (FVC%; r(s) = -0.38), and percent-predicted forced expiratory volume in 1 s (FEV(1)%; r(s) = -0.36). Serum M30 levels were correlated with radiological ground-glass opacity scores (r(s) = 0.61).



CONCLUSION: The epithelial apoptosis marker serum level was correlated with IIP clinical status and is a potential marker to assess IIP.
MeSH terms
AgedApoptosis/*physiologyBiological Markers/bloodEnzyme-Linked Immunosorbent AssayEpithelial Cells/*pathologyFemaleForced Expiratory Volume/physiologyHumansIdiopathic Interstitial Pneumonias/blood/*pathology/physiopathologyKeratin-18/*bloodMaleMiddle AgedSpirometryTomography, X-Ray Computed
DOI
10.1016/j.rmed.2010.05.013
PMID
20542676
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
정, 우영선, 주성박, 주헌이, 규성신, 승수박, 경주황, 성철이, 기범박, 광주
Full Text Link
Files in This Item:
20542676.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse