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Efficacy of high-dose chemotherapy and autologous stem cell transplantation in patients with relapsed medulloblastoma: a report on the Korean Society for Pediatric Neuro-Oncology (KSPNO)-S-053 study.

Authors
Park, JE; Kang, J; Yoo, KH; Sung, KW; Koo, HH; Lim, do H; Shin, HJ; Kang, HJ; Park, KD; Shin, HY; Kim, IH; Cho, BK; Im, HJ; Seo, JJ; Park, HJ; Park, BK; Ahn, HS
Citation
Journal of Korean medical science, 25(8):1160-1166, 2010
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
The efficacy and toxicity of high-dose chemotherapy and autologous stem cell transplantation (HDCT/ASCT) were investigated for improving the outcomes of patients with relapsed medulloblastoma. A total of 15 patients with relapsed medulloblastoma were enrolled in the KSPNO-S-053 study from May 2005 to May 2007. All patients received approximately 4 cycles of salvage chemotherapy after relapse. Thirteen underwent HDCT/ASCT; CTE and CM regimen were employed for the first HDCT (HDCT1) and second HDCT (HDCT2), respectively, and 7 underwent HDCT2. One transplant related mortality (TRM) due to veno-occlusive disease (VOD) occurred during HDCT1 but HDCT2 was tolerable with no further TRM. The 3-yr overall survival probability and event-free survival rates +/-95% confidence intervals (CI) were 33.3+/-12.2% and 26.7% +/-11.4%, respectively. When analysis was confined to only patients who had a complete response (CR) or partial response (PR) prior to HDCT, the probability of 3-yr overall survival rates +/-95% CI was 40.0+/-15.5%. No patients with stable disease (SD) or progressive disease (PD) survived. Survival rates from protocol KSPNO-S-053 are encouraging and show that tumor status prior to HDCT/ASCT is an important factor to consider for improving survival rates of patients with relapsed medulloblastoma.
MeSH terms
AdolescentCerebellar Neoplasms/drug therapy/mortality/*therapyChildChild, PreschoolCombined Modality TherapyDisease-Free SurvivalFemale*Hematopoietic Stem Cell TransplantationHumansMaleMedulloblastoma/drug therapy/mortality/*therapyNeoplasm Recurrence, Local/drug therapy/mortality/*therapyRepublic of KoreaSalvage TherapyTransplantation, AutologousYoung Adult
DOI
10.3346/jkms.2010.25.8.1160
PMID
20676326
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
AJOU Authors
박, 준은
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