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Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: emergence of a novel OXA-182.

Kim, CK; Lee, Y; Lee, H; Woo, GJ; Song, W; Kim, MN; Lee, WG; Jeong, SH; Lee, K; Chong, Y
Diagnostic microbiology and infectious disease, 68(4):432-438, 2010
Journal Title
Diagnostic microbiology and infectious disease
Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-β-lactamase (MBL)-producing isolates. bla(OXA)-₂₃-like and ISAba1-asssociated bla(OXA)-₅₁-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel bla(OXA)-₁₈₂ was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumanniiAcinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with bla(OXA)-₂₃-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.
MeSH terms
Acinetobacter/classification/drug effects/*enzymology/isolation & purificationAcinetobacter Infections/*epidemiology/microbiologyAmino Acid SequenceAnti-Bacterial Agents/*pharmacologyBacterial Proteins/biosynthesis/chemistry/classification/*geneticsDNA, Bacterial/analysis/geneticsDrug Resistance, Bacterial/*geneticsGenetic VariationHumansImipenem/*pharmacologyMicrobial Sensitivity TestsMolecular Sequence DataPolymerase Chain Reaction/methodsPrevalenceRepublic of Korea/epidemiologySpecies Specificitybeta-Lactamases/biosynthesis/chemistry/classification/*genetics
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Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
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이, 위교
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