43 351

Cited 2 times in

Linkage and association studies of joint morbidity from rheumatoid arthritis.

Authors
Min, JY; Min, KB; Sung, J; Cho, SI
Citation
The Journal of rheumatology, 37(2):291-295, 2010
Journal Title
The Journal of rheumatology
ISSN
0315-162X
Abstract
OBJECTIVE: To investigate the relationship between genetic variations of rheumatoid arthritis (RA) susceptibility in terms of joint morbidity.



METHODS: We used data from Genetic Analysis Workshop 15. The Illumina linkage panel IV included 5858 single-nucleotide polymorphisms (SNP), with 5744 SNP passing quality control filters. The phenotypic variables analyzed were the level of rheumatoid factor (RF) and score on the Joint Alignment and Motion (JAM) scale. We modified the scale, dividing by RF values relevant to disease severity. Linkage analysis for affected sibling pairs was done using the MERLIN program, and family-based association tests were carried out using PLINK and FBAT software.



RESULTS: We found a high peak (LOD = 3.29; NPL Z = 4.07) near the HLA-DRB1 region on chromosome 6. The linkage at 6p24 at rs1410766 [LOD = 2.66; nonparametric linkage (NPL) Z = 3.23] was statistically significant. Two other regions also showed possible linkage peaks: chromosome 7q30 at rs322812 (LOD = 2.47; NPL Z = 3.39) and chromosome 15p34 at rs347117 (LOD = 1.95; NPL Z = 2.80). For the family-based association study, 7 SNP related to clinical RA severity were detected.



CONCLUSION: Genetic variations may lead to an enhanced risk of joint damage and increased levels of RF. Further studies are needed to elucidate the roles of other genes involved in RA and to explore whether the clinical signs of RA are associated with particular genetic variations.
MeSH terms
AdultAge of OnsetArthritis, Rheumatoid/blood/*genetics/immunologyChromosome MappingGenetic Association Studies*Genetic LinkageGenetic Predisposition to DiseaseHumansJoints/*immunologyPolymorphism, Single Nucleotide/geneticsRheumatoid Factor/immunologySeverity of Illness IndexSiblings
DOI
10.3899/jrheum.090526
PMID
20032104
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Occupational & Environmental Medicine
AJOU Authors
민, 경복
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse