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Young girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy.

DC Field Value Language
dc.contributor.authorYoo, SC-
dc.contributor.authorKim, WY-
dc.contributor.authorYoon, JH-
dc.contributor.authorChang, SJ-
dc.contributor.authorChang, KH-
dc.contributor.authorRyu, HS-
dc.date.accessioned2011-06-07T04:43:05Z-
dc.date.available2011-06-07T04:43:05Z-
dc.date.issued2010-
dc.identifier.issn0001-6349-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2817-
dc.description.abstractAbstract Objective. To evaluate the long-term outcome and ovarian function in premenarchal and adolescent patients with malignant ovarian germ cell tumors after fertility-preserving surgery and adjuvant chemotherapy. Design. Retrospective review of medical records. Setting. Ajou University Hospital, a tertiary care hospital in South Korea. Population. Forty-five patients with malignant ovarian germ cell tumors. Methods. A retrospective analysis of patients with malignant ovarian germ cell tumors was conducted and a statistical analysis was performed. Main outcome measures. There were 9 premenarchal and 16 adolescent patients; the median ages at diagnosis were 7 and 18 years, respectively. All patients were treated with fertility-preserving surgery. Seventeen of the patients received adjuvant chemotherapy with bleomycin, etoposide, and cisplatin (68.0%). There were no disease recurrences or deaths. Of the nine premenarchal patients, eight (88.9%) subsequently had normal menarche. Among the 16 adolescent patients, 15 (93.8%) resumed normal menstruation and 1 had premature ovarian failure. Conclusion. Premenarchal and adolescent patients with malignant ovarian germ cell tumors have excellent survival with fertility-preserving surgery and adjuvant chemotherapy. The majority of these patients can have normal menarche and menstruation.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLymph Node Excision-
dc.subject.MESHMenarche-
dc.subject.MESHMenstruation-
dc.subject.MESHNeoplasms, Germ Cell and Embryonal-
dc.subject.MESHOvarian Neoplasms-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTeratoma-
dc.subject.MESHTumor Markers, Biological-
dc.titleYoung girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy.-
dc.typeArticle-
dc.identifier.pmid19878051-
dc.contributor.affiliatedAuthor유, 승철-
dc.contributor.affiliatedAuthor김, 우영-
dc.contributor.affiliatedAuthor윤, 종혁-
dc.contributor.affiliatedAuthor장, 석준-
dc.contributor.affiliatedAuthor장, 기홍-
dc.contributor.affiliatedAuthor유, 희석-
dc.type.localJournal Papers-
dc.identifier.doi10.3109/00016340903348383-
dc.citation.titleActa obstetricia et gynecologica Scandinavica-
dc.citation.volume89-
dc.citation.number1-
dc.citation.date2010-
dc.citation.startPage126-
dc.citation.endPage130-
dc.identifier.bibliographicCitationActa obstetricia et gynecologica Scandinavica, 89(1). : 126-130, 2010-
dc.identifier.eissn1600-0412-
dc.relation.journalidJ000016349-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Humanities & Social Medicine
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