c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma.
Kim, CH; Koh, YW; Han, JH; Kim, JW; Lee, JS; Baek, SJ; Hwang, HS; Choi, EC
Head & neck, 32(12):1655-1664, 2010
Head & neck
BACKGROUND: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT).
METHODS: Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT.
RESULTS: The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot.
CONCLUSION: The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.
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