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c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma.

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dc.contributor.authorKim, CH-
dc.contributor.authorKoh, YW-
dc.contributor.authorHan, JH-
dc.contributor.authorKim, JW-
dc.contributor.authorLee, JS-
dc.contributor.authorBaek, SJ-
dc.contributor.authorHwang, HS-
dc.contributor.authorChoi, EC-
dc.date.accessioned2011-06-08T06:13:13Z-
dc.date.available2011-06-08T06:13:13Z-
dc.date.issued2010-
dc.identifier.issn1043-3074-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2857-
dc.description.abstractBACKGROUND: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT).



METHODS: Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT.



RESULTS: The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot.



CONCLUSION: The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCarcinoma, Squamous Cell-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHepatocyte Growth Factor-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHProto-Oncogene Proteins c-met-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTongue Neoplasms-
dc.subject.MESHYoung Adult-
dc.titlec-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma.-
dc.typeArticle-
dc.identifier.pmid20848408-
dc.contributor.affiliatedAuthor김, 철호-
dc.contributor.affiliatedAuthor한, 재호-
dc.contributor.affiliatedAuthor이, 진석-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/hed.21383-
dc.citation.titleHead & neck-
dc.citation.volume32-
dc.citation.number12-
dc.citation.date2010-
dc.citation.startPage1655-
dc.citation.endPage1664-
dc.identifier.bibliographicCitationHead & neck, 32(12). : 1655-1664, 2010-
dc.identifier.eissn1097-0347-
dc.relation.journalidJ010433074-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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