Cited 0 times in Scipus Cited Count

c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma.

Authors
Kim, CH  | Koh, YW | Han, JH  | Kim, JW | Lee, JS  | Baek, SJ | Hwang, HS | Choi, EC
Citation
Head & neck, 32(12). : 1655-1664, 2010
Journal Title
Head & neck
ISSN
1043-30741097-0347
Abstract
BACKGROUND: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT).



METHODS: Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT.



RESULTS: The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot.



CONCLUSION: The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.
MeSH

DOI
10.1002/hed.21383
PMID
20848408
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Ajou Authors
김, 철호  |  이, 진석  |  한, 재호
Files in This Item:
There are no files associated with this item.
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse