46 287

Cited 113 times in

Induction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells.

Kim, CH; Bahn, JH; Lee, SH; Kim, GY; Jun, SI; Lee, K; Baek, SJ
Journal of biotechnology, 150(4):530-538, 2010
Journal Title
Journal of biotechnology
Plasma is generated by ionizing neutral gas molecules, resulting in a mixture of energy particles, including electrons and ions. Recent progress in the understanding of non-thermal atmospheric plasma has led to applications in biomedicine. However, the exact molecular mechanisms involved in plasma-induced cell growth arrest are unclear. In this study, we investigated the feasibility of non-thermal atmospheric plasma treatment for cancer therapy and examined the mechanism by which plasma induces anti-proliferative properties and cell death in human colorectal cancer cells. Non-thermal atmospheric plasma induced cell growth arrest and induced apoptosis. In addition, plasma reduced cell migration and invasion activities. As a result, we found that plasma treatment to the cells increases β-catenin phosphorylation, suggesting that β-catenin degradation plays a role at least in part in plasma-induced anti-proliferative activity. Therefore, non-thermal atmospheric plasma constitutes a new biologic tool with the potential for therapeutic applications that modulate cell signaling and function.
MeSH terms
Blotting, WesternCell Line, TumorCell Movement/physiology*Cell ProliferationColorectal Neoplasms/*therapyFlow CytometryHumansIn Situ Nick-End LabelingIndolesPhosphorylationPlasma Gases/*therapeutic useSignal Transduction/*physiologybeta Catenin/metabolism
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
AJOU Authors
김, 철호
Full Text Link
RIS (EndNote)
XLS (Excel)


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.