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Induction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells.

Authors
Kim, CH; Bahn, JH; Lee, SH; Kim, GY; Jun, SI; Lee, K; Baek, SJ
Citation
Journal of biotechnology, 150(4):530-538, 2010
Journal Title
Journal of biotechnology
ISSN
0168-16561873-4863
Abstract
Plasma is generated by ionizing neutral gas molecules, resulting in a mixture of energy particles, including electrons and ions. Recent progress in the understanding of non-thermal atmospheric plasma has led to applications in biomedicine. However, the exact molecular mechanisms involved in plasma-induced cell growth arrest are unclear. In this study, we investigated the feasibility of non-thermal atmospheric plasma treatment for cancer therapy and examined the mechanism by which plasma induces anti-proliferative properties and cell death in human colorectal cancer cells. Non-thermal atmospheric plasma induced cell growth arrest and induced apoptosis. In addition, plasma reduced cell migration and invasion activities. As a result, we found that plasma treatment to the cells increases β-catenin phosphorylation, suggesting that β-catenin degradation plays a role at least in part in plasma-induced anti-proliferative activity. Therefore, non-thermal atmospheric plasma constitutes a new biologic tool with the potential for therapeutic applications that modulate cell signaling and function.
MeSH terms
Blotting, WesternCell Line, TumorCell Movement/physiology*Cell ProliferationColorectal Neoplasms/*therapyFlow CytometryHumansIn Situ Nick-End LabelingIndolesPhosphorylationPlasma Gases/*therapeutic useSignal Transduction/*physiologybeta Catenin/metabolism
DOI
10.1016/j.jbiotec.2010.10.003
PMID
20959125
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
AJOU Authors
김, 철호
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