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Efficacy of adjuvant gemcitabine-cisplatin chemotherapy: a comparative study between locally advanced transitional cell carcinoma of the bladder and upper urinary tract.

Authors
Song, YS; Cho, JS; Cho, KS; Doo, SH; Chung, BH; Kim, SJ; Yang, WJ; Song, KH; Kim, CI; Hong, SJ
Citation
Urologia internationalis, 85(1):47-51, 2010
Journal Title
Urologia internationalis
ISSN
0042-11381423-0399
Abstract
OBJECTIVE: To evaluate the comparative efficacy of adjuvant gemcitabine and cisplatin (GC) chemotherapy between patients with locally advanced transitional cell carcinoma (TCC) of the bladder and upper urinary tract.



PATIENTS AND METHODS: From 2001 to 2005, we retrospectively selected a total of 64 patients with locally advanced TCC of the bladder and upper urinary tract who received at least 3 cycles of adjuvant GC chemotherapy. We compared disease-free and overall survival between the 2 groups.



RESULTS: The recurrence rate was 30.3% in TCC of the bladder and 25.8% of the upper urinary tract (p = 0.633). Statistical analysis revealed that there was no significant difference in the disease-free or overall survival rate between TCC of the bladder and upper urinary tract treated with adjuvant GC chemotherapy.



CONCLUSION: Under the circumstances of limited data about TCC of the upper urinary tract, this study may suggest that adjuvant GC chemotherapy in locally advanced TCC of the upper urinary tract is as effective as those of bladder.
MeSH terms
AdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic useCarcinoma, Transitional Cell/*drug therapy/mortality/pathology/surgeryChemotherapy, AdjuvantChi-Square DistributionCisplatin/administration & dosageDeoxycytidine/administration & dosage/analogs & derivativesDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingRepublic of KoreaRetrospective StudiesRisk AssessmentRisk FactorsSurvival RateTime FactorsTreatment OutcomeUrinary Bladder Neoplasms/*drug therapy/mortality/pathology/surgeryUrologic Neoplasms/*drug therapy/mortality/pathology/surgery
DOI
10.1159/000296294
PMID
20234122
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
AJOU Authors
김, 세중
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