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Effect-site concentration of propofol for reduction of remifentanil-induced cough.

Authors
Kim, JY; Lee, SY; Kim, DH; Park, SK; Min, SK
Citation
Anaesthesia, 65(7):697-703, 2010
Journal Title
Anaesthesia
ISSN
0003-24091365-2044
Abstract
SUMMARY: This study examined the effectiveness of different propofol infusion target concentrations on cough suppression, during a target-controlled remifentanil infusion. Four hundred patients were randomly assigned to receive propofol target effect-site concentrations of 0, 3.0, 4.5, or 6.0 microgxml(-1). When the propofol effect-site concentration reached the target, remifentanil was administered at a target effect-site concentration of 4.0 ngxml(-1). Episodes of cough were recorded over a 2-min period after remifentanil commencement, and graded as mild (1-2), moderate (3-4), or severe (5 or more). The overall incidence of cough was significantly decreased in by propofol 6.0 microgxml(-1) compared with 0 or 3.0 microgxml(-1) propofol (p < 0.001). The incidence of severe cough was significantly lower with propofol 6.0 microgxml(-1) compared with 3.0 microgxml(-1) (p = 0.03). A propofol target effect-site concentration of 6.0 microgxml(-1) effectively suppressed remifentanil-induced cough when remifentanil was administrated at a target effect-site concentration of 4.0 ngxml(-1).
MeSH terms
AdolescentAdultAgedAnesthesia, General/methodsAnesthetics, Intravenous/*administration & dosage/*adverse effects/bloodBlood Pressure/drug effectsCough/blood/chemically induced/*prevention & controlDose-Response Relationship, DrugDrug Administration ScheduleHeart Rate/drug effectsHumansMiddle AgedOxygen/bloodPartial PressurePiperidines/*adverse effects/bloodPropofol/*administration & dosageSeverity of Illness IndexYoung Adult
DOI
10.1111/j.1365-2044.2010.06347.x
PMID
20477784
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
김, 종엽이, 숙영김, 대희민, 상기
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