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Does long-term lactation protect premenopausal women against hypertension risk? A Korean women's cohort study.

Lee, SY; Kim, MT; Jee, SH; Yang, HP
Preventive medicine, 41(2):433-438, 2005
Journal Title
Preventive medicine
BACKGROUND: Little is known about the long-term effect of lactation on maternal cardiovascular health except for a few animal or human experimental studies. The objective of this study was to examine the effects of lactation on the incidence of hypertension in premenopausal women.
METHODS: The data were derived from a cohort study with 6 years follow-up (1995-2000). The cohort was composed of 177,749 Korean premenopausal women, aged 20-59, who had medical evaluations in 1992 and 1994. During the follow-up, blood pressure was measured as part of the 1996, 1998, and 2000 periodic examinations.
RESULTS: In multivariate Cox proportional hazard models, lactation decreased the risk of hypertension (risk ratio, 0.92; 95% confidence interval, 0.90-0.96). Compared with women who with no history of lactation, 1-6 months of lactation decreased the risk of hypertension (RR, 0.90; 95% CI, 0.87-0.93), as did 7-12 months (RR, 0.92; 95% CI, 0.87-0.98) or 13-18 months (RR, 0.93; 95% CI, 0.86-0.99). In particular, the coexistence of obesity and no lactation increased the risk of hypertension (P for interaction = 0.028).
CONCLUSION: This finding suggests that lactation may be a protective factor against hypertension among premenopausal women.
MeSH terms
AdultFemaleHumansHypertension/epidemiology*Hypertension/prevention & controlIncidenceKorea/epidemiologyLactation/physiology*Middle AgedMultivariate AnalysisObesity/physiopathologyPremenopause*Proportional Hazards ModelsProspective StudiesRisk
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Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
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