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Gabapentin reduces rectal mechanosensitivity and increases rectal compliance in patients with diarrhoea-predominant irritable bowel syndrome.

Authors
Lee, KJ; Kim, JH; Cho, SW
Citation
Alimentary pharmacology & therapeutics, 22(10):981-988, 2005
Journal Title
Alimentary pharmacology & therapeutics
ISSN
0269-28131365-2036
Abstract
BACKGROUND: Gabapentin has been shown to reduce elements of central sensitization in human experimental hyperalgesia. It remains uninvestigated whether gabapentin has beneficial effects for irritable bowel syndrome associated with visceral hypersensitivity.



AIMS: To evaluate the effects of gabapentin on sensory and motor function of the rectum in patients with diarrhoea-predominant irritable bowel syndrome.



METHODS: Forty patients with diarrhoea-predominant irritable bowel syndrome completed this randomized, double-blind, placebo-controlled, parallel-grouped study. All patients received a barostat study and were subsequently randomized for 5-day treatment with gabapentin 300 mg/day and then 600 mg/day or placebo. On day 6, after subjects had their morning dose, the barostat experiment was repeated.



RESULTS: The threshold pressures for bloating, discomfort and pain significantly increased after gabapentin, but not after placebo. Significant increase in the pressure and corresponding wall tension inducing discomfort or pain were observed in the gabapentin group, but not in the placebo group. Rectal compliance significantly increased after gabapentin, but not after placebo. The postprandial increase of rectal tone was not affected by gabapentin.



CONCLUSION: Our results show that gabapentin reduces rectal sensory thresholds through attenuating rectal sensitivity to distension and enhancing rectal compliance in diarrhoea-predominant irritable bowel syndrome patients. The clinical efficacy of this drug in irritable bowel syndrome patients warrants investigation.
MeSH terms
AdultAmines/administration & dosage*Analgesics/administration & dosage*ComplianceCyclohexanecarboxylic Acids/administration & dosage*Diarrhea/drug therapyDiarrhea/physiopathology*Double-Blind MethodHumansIrritable Bowel Syndrome/drug therapyIrritable Bowel Syndrome/physiopathology*Pain Measurement/drug effectsQuestionnairesRectum/drug effects*Rectum/physiologySensory Thresholds/drug effects*gamma-Aminobutyric Acid/administration & dosage*
DOI
10.1111/j.1365-2036.2005.02685.x
PMID
16268973
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
이, 광재김, 진홍조, 성원
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