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Forskolin promotes astroglial differentiation of human central neurocytoma cells.

Authors
Kim, BJ; Kim, SS; Kim, YI; Paek, SH; Lee, YD; Suh-Kim, H
Citation
Experimental & molecular medicine, 36(1):52-56, 2004
Journal Title
Experimental & molecular medicine
ISSN
1226-36132092-6413
Abstract
Human central neurocytoma is a kind of the brain tumors that are usually found in anterior part of the lateral ventricles. In this study, we established conditions that allowed proliferation of neurocytoma cells culture and analyzed characteristics of neurocytoma cells in vitro. For in vitro, a condition that used for culturing neural stem cells and contained basic fibroblast growth factor (bFGF) provided high proliferation. RT-PCR analaysis showed that nestin was found in neurocytoma cells, indicating that the neurocytomas possess neural stem cell properties. Interestingly, treatment of neurocytoma cells with forskolin increased expression of glial fibrillary acidic protein with a concomitant decrease in the nestin expression. Forskolin also induced morphological changes of neurocytoma cells to adopt an astrocyte-like phenotype. The results suggest that neurocyotma cells may have properties of multipotent neural stem cells.
MeSH terms
AnimalsAstrocytes/cytology/*physiologyCell Differentiation/*drug effectsCell ProliferationCell ShapeFibroblast Growth Factor 2/pharmacologyForskolin/*pharmacology/*therapeutic useHumansIntermediate Filament Proteins/metabolismNerve Tissue Proteins/metabolismNeurocytoma/*drug therapy/pathologyTumor Cells, Cultured
DOI
10.1038/emm.2004.7
PMID
15031671
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
AJOU Authors
김, 성수이, 영돈서, 해영
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