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Circulating beta amyloid protein is elevated in patients with acute ischemic stroke.

Authors
Lee, PH; Bang, OY; Hwang, EM; Lee, JS; Joo, US; Mook-Jung, I; Huh, K
Citation
Journal of neural transmission, 112(10):1371-1379, 2005
Journal Title
Journal of neural transmission
Abstract
Recent clinical and experimental studies suggest that ischemic strokes may play an important role in the pathogenesis of Alzheimer's disease (AD). Beta amyloid (Abeta), a major component of senile plaque in AD, is known to be derived from ischemic brain or activated platelets. We prospectively enrolled 62 patients with acute ischemic stroke and 27 age-matched controls. The serum Abeta and P-selectin levels were determined using the Sandwich-ELISA. We divided ischemic strokes into subgroups according to the clinical syndrome, pathogenesis, and infarct size, and compared the Abeta level between each subgroup. The Abeta1-40 level was markedly elevated in ischemic stroke patients, as compared to controls (140.2 +/- 54.0 vs 88.44 +/- 34.96 pg/ml, p<0.001). Cardioembolic and larger artery atherosclerotic infarcts had higher Abeta1-40 level than small vessel disease (p = 0.001). Both infarct size and the initial NIHSS score had significantly positive correlations with the serum level of Abeta1-40 (r = 0.539, p<0.001 and r = 0.425, p = 0.001, respectively). However, the P-selectin level was not significantly correlated with serum Abeta1-40. Our data suggest that elevated circulating Abeta1-40 in ischemic stroke patients may be derived from brain as a consequence of ischemic insults.
MeSH terms
Acute DiseaseAgedAmyloid beta-Peptides/blood*Biological Markers/bloodBrain Ischemia/epidemiologyBrain Ischemia/metabolism*Brain Ischemia/pathologyFemaleHumansMaleMiddle AgedP-Selectin/bloodPeptide Fragments/blood*Platelet ActivationProspective StudiesRisk FactorsSeverity of Illness IndexStroke/epidemiologyStroke/metabolism*Stroke/pathology
DOI
10.1007/s00702-004-0274-0
PMID
15682267
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
이, 필휴방, 오영허, 균
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