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The course of patients with lacunar infarcts and a parent arterial lesion: similarities to large artery vs small artery disease.

DC Field Value Language
dc.contributor.authorBang, OY-
dc.contributor.authorJoo, SY-
dc.contributor.authorLee, PH-
dc.contributor.authorJoo, US-
dc.contributor.authorLee, JH-
dc.contributor.authorJoo, IS-
dc.contributor.authorHuh, K-
dc.date.accessioned2011-06-30T04:11:16Z-
dc.date.available2011-06-30T04:11:16Z-
dc.date.issued2004-
dc.identifier.issn0003-9942-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3142-
dc.description.abstractBACKGROUND: The significance of occlusive lesions of the parent artery in patients with lacunar syndrome (LS) and small deep infarcts (SDIs) on diffusion-weighted imaging remains unclear.



OBJECTIVE: To compare the recurrence of stroke in patients with LS and SDIs between those with vs without a parent arterial lesion.



DESIGN: Analysis of data from a prospective acute stroke registry.



SETTING: University hospital.



PATIENTS: Using clinical syndrome, diffusion-weighted imaging, and vascular studies, we divided 173 patients into 3 groups: (1) parent arterial disease occluding deep perforators (PAD), LS with SDIs, and a parent arterial lesion (n = 32); (2) small artery disease (SAD) (n = 70); and (3) large artery disease (LAD) (n = 71).



MAIN OUTCOME MEASURES: Recurrent strokes and the prognosis were registered for 1 year, and the outcome of the PAD group was compared with that of the SAD and LAD groups.



RESULTS: During follow-up, there were 9 deaths (6 vascular) and 18 recurrent strokes. The recurrence rate in the PAD group (16%) was significantly higher than that in the SAD group (1%) (P =.01) but similar to that in the LAD group (17%) (P =.87). The presence of the parent arterial lesion was the only independent predictor of stroke recurrence in patients with LS and SDIs (odds ratio, 13.8; 95% confidence interval, 1.5-123.9; P =.02).



CONCLUSIONS: Although LS on examination, SDIs on diffusion-weighted imaging, and a stable hospital course suggest lacunar stroke of benign course, our results indicate that the PAD group represents an intracranial type of LAD.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHArterial Occlusive Diseases/*complications/diagnosis/mortality-
dc.subject.MESHBrain Infarction/diagnosis/*etiology/mortality-
dc.subject.MESHCerebral Arterial Diseases/*complications/diagnosis/mortality-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESH*Diffusion Magnetic Resonance Imaging-
dc.subject.MESHDominance, Cerebral/physiology-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHRecurrence-
dc.subject.MESHRisk Factors-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSurvival Rate-
dc.titleThe course of patients with lacunar infarcts and a parent arterial lesion: similarities to large artery vs small artery disease.-
dc.typeArticle-
dc.identifier.pmid15096399-
dc.identifier.urlhttp://archneur.ama-assn.org/cgi/pmidlookup?view=long&pmid=15096399-
dc.contributor.affiliatedAuthor방, 오영-
dc.contributor.affiliatedAuthor이, 필휴-
dc.contributor.affiliatedAuthor주, 인수-
dc.contributor.affiliatedAuthor허, 균-
dc.type.localJournal Papers-
dc.identifier.doi10.1001/archneur.61.4.514-
dc.citation.titleArchives of neurology-
dc.citation.volume61-
dc.citation.number4-
dc.citation.date2004-
dc.citation.startPage514-
dc.citation.endPage519-
dc.identifier.bibliographicCitationArchives of neurology, 61(4):514-519, 2004-
dc.identifier.eissn1538-3687-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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