33 340

Cited 0 times in

Leukomelanoderma following acute cutaneous graft-versus-host disease.

Authors
Kang, HY; Kang, WH
Citation
European journal of dermatology : EJD, 14(3):146-149, 2004
Journal Title
European journal of dermatology : EJD
ISSN
1167-11221952-4013
Abstract
Acute graft versus host disease (GVHD) is characterized by a selective epithelial inflammation that can affect the skin, digestive tract, and liver. Development of pigmentary abnormalities can be observed in sites where acute cutaneous GVHD has occurred, and usually consists of hyperpigmented spots. We observed atypical pigmetary changes consisting of a combination of hyper- and hypopigmentation, so called leukomelanoderma, in a young allogeneic bone marrow recipient who suffered repetitive acute GVHD. The histopathological examinations showed features of a post-inflammatory process. Because keratinocytes produce inflammatory cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-1alpha, which may be implicated in the inflammatory phenomena seen in acute GVHD, we studied whether these inflammatory cytokines might be implicated in these pigmentary changes. The cytokines tested were IL-1alpha, IL-2, TNF-alpha and IL-10. The expression of TNF-alpha increased in the hyperpigmented skin relative to normal and hypopigmented skin. While TNF-alpha was variably distributed in proportion to different degrees of pigmentation, other molecules were detected at minimal levels in all samples. This observation may indicate that the production of TNF-alpha by epidermal microenvironment may be involved in postinflammatory pigmentary changes.
MeSH terms
AdultBone Marrow TransplantationDiagnosis, DifferentialFaceGraft vs Host Disease/*complicationsHumansImmunohistochemistryMaleMelanosis/*diagnosis/etiology/metabolism/pathologyPrecursor Cell Lymphoblastic Leukemia-Lymphoma/therapyThoraxTumor Necrosis Factor-alpha/metabolism
PMID
15246938
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
강, 희영
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse