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Survivin, a novel anti-apoptosis inhibitor, expression in uterine cervical cancer and relationship with prognostic factors.

Authors
Lee, JP; Chang, KH; Han, JH; Ryu, HS
Citation
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 15(1):113-119, 2005
Journal Title
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
ISSN
1048-891X1525-1438
Abstract
A novel inhibitor of apoptosis, Survivin, seems to be involved in the critical steps of cancer onset and progression and may be associated with unfavorable clinical outcome. We investigated the expression of Survivin in patients with cervical intraepithelial neoplasia grade 3 (CIN3) and uterine cervical cancer, to determine whether Survivin expression is related to poor prognosis. Fourteen cases of CIN3, 53 cases of invasive uterine cervical squamous cell carcinoma (SCC), and 11 cases of normal control group were analyzed retrospectively. Immunohistochemical staining and Western blot was performed with antihuman Survivin antibody and analyzed with respect to patient outcome. Survivin was significantly expressed in cervical cancer groups compared to the normal control group (P or =4 cm, lymphovascular invasion, elevated SCC antigen levels, and no response to initial therapy. In more advanced stages, Survivin expression tended to increase but without statistical significance (P = 0.081). No association was noted between Survivin expression and survival rate (P = 0.1011). We conclude that Survivin expression provides some prognostic information regarding uterine cervical cancer, even though it was not correlated with survival. It could represent a possible new prognostic marker of uterine cervical SCC patients.
MeSH terms
AdultApoptosisCarcinoma, Squamous Cell/metabolism*Carcinoma, Squamous Cell/pathologyCervical Intraepithelial Neoplasia/metabolism*Cervical Intraepithelial Neoplasia/pathologyFemaleHumansMicrotubule-Associated Proteins/metabolism*Middle AgedNeoplasm Proteins/metabolism*Neoplasm StagingPrognosisRetrospective StudiesRisk FactorsSurvival AnalysisTumor Markers, Biological/metabolism*
DOI
10.1111/j.1048-891X.2005.15011.x
PMID
15670305
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
이, 정필장, 기홍한, 재호유, 희석
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