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Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships.

Authors
Park, KH; Choi, SE; Eom, M; Kang, Y
Citation
Breast cancer research : BCR, 7(2):R238-R247, 2005
Journal Title
Breast cancer research : BCR
ISSN
1465-54111465-542X
Abstract
INTRODUCTION: The anaphase-promoting complex (APC) is a multiprotein complex with E3 ubiquitin ligase activity, which is required for the ubiquitination of securin and cyclin-B. Moreover, the mitotic spindle checkpoint is activated if APC activation is prevented. In addition, several APC-targeting molecules such as securin, polo-like kinase, aurora kinase, and SnoN have been reported to be oncogenes. Therefore, dysregulation of APC may be associated with tumorigenesis. However, the clinical significance and the involvement of APC in tumorigenesis have not been investigated.



METHODS: The expression of APC7 was immunohistochemically investigated in 108 invasive ductal carcinomas of the breast and its relationship with clinicopathologic parameters was examined. The expression of APC7 was defined as positive when the summed scores of staining intensities (0 to 3+) and stained proportions (0 to 3+) exceeded 3+.



RESULTS: Positive APC7 expression was less frequent than its negative expression when histologic (P = 0.009) or nuclear grade (P = 0.009), or mitotic number (P = 0.0016) was elevated. The frequency of APC7 negative expression was higher in high Ki-67 or aneuploid groups than in low Ki-67 or diploid groups.



CONCLUSION: These data show that loss of APC7 expression is more common in breast carcinoma cases with poor prognostic parameters or malignant characteristics. They therefore suggest that dysregulation of APC activity, possibly through downregulation of APC7, may be associated with tumorigenesis in breast cancer.
MeSH terms
AdultAgedAneuploidyBreast Neoplasms/genetics*Breast Neoplasms/pathology*Carcinoma, Ductal, Breast/genetics*Carcinoma, Ductal, Breast/pathology*Cell Transformation, Neoplastic/geneticsDown-RegulationFemaleGene Expression ProfilingHumansImmunohistochemistryKi-67 Antigen/analysisMiddle AgedNeoplasm StagingPrognosisUbiquitin-Protein Ligase Complexes/geneticsUbiquitin-Protein Ligase Complexes/physiology*
DOI
10.1186/bcr978
PMID
15743504
Appears in Collections:
Journal Papers > Research Organization > Chronic Inflammatory Disease Research Center
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
최, 성이강, 엽
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