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Glucose uptake-stimulatory activity of Amomi Semen in 3T3-L1 adipocytes.

Authors
Kang, Y; Kim, HY
Citation
Journal of ethnopharmacology, 92(1):103-105, 2004
Journal Title
Journal of ethnopharmacology
ISSN
0378-87411872-7573
Abstract
Amomi Semen has been used as a folk remedy for the treatment of diabetes in Korea. The aim of this study was to examine whether it had an enhancing effect on glucose uptake, an essential process of insulin action. Its aqueous ethanolic extract significantly stimulated glucose uptake in 3T3-L1 adipocytes at the concentration of 0.5 mg/ml. The extract significantly potentiated insulin-stimulated glucose uptake with a dose-dependent manner at a concentration range from 0.02 to 0.5 mg/ml. The results suggest that the antidiabetic action of Amomi may be mediated through the stimulation of glucose uptake and the potentiation of insulin action.
MeSH terms
3T3 Cells/drug effects/metabolismAdipocytes/drug effects/metabolism*AmomumAnimalsDiabetes Mellitus, Type 2/*prevention & controlDose-Response Relationship, DrugGlucose/*metabolismHypoglycemic Agents/administration & dosage/*pharmacology/therapeutic useInsulin/pharmacologyMice*PhytotherapyPlant Extracts/administration & dosage/*pharmacology/therapeutic useSeeds
DOI
10.1016/j.jep.2004.02.003
PMID
15099855
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
강, 엽
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