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Frequency and mechanisms of stroke recurrence after cryptogenic stroke.

Authors
Bang, OY; Lee, PH; Joo, SY; Lee, JS; Joo, IS; Huh, K
Citation
Annals of neurology, 54(2):227-234, 2003
Journal Title
Annals of neurology
ISSN
0364-51341531-8249
Abstract
The purpose of this study was to better understand the frequency and mechanisms of stroke recurrence after the stroke with no determined cause (NC). We prospectively studied consecutive patients with acute cerebral infarcts. We divided the patients into five groups (large artery disease [LAD], cardioembolism [CE], small artery disease [SAD], two or more causes [TMC], and NC) and registered recurrent strokes and prognosis for 1 year. Those in the NC group were compared with other subtypes. A total of 204 patients were included; 56 LAD, 22 CE, 62 SAD, 27 TMC, and 37 NC. During follow-up, there were 7 deaths and 31 first recurrent strokes. Patients of the NC group showed a significantly higher rate (30%) of recurrent stroke than those of other subtypes (LAD 16%; CE 14%; SAD 2%), and it was associated with the existence of mild stenosis (</=50%) on relevant artery or the stenosis of greater than 50% on nonrelevant artery. Occlusive lesions other than significant stenosis of relevant artery may play an important role in the development of stroke recurrence in patients of the NC group. Therefore, from the therapeutic and prognostic point of view, the detection of such occlusive lesions in patients with cryptogenic stroke may be needed.
MeSH terms
AgedAged, 80 and overArterial Occlusive Diseases/complicationsArterial Occlusive Diseases/pathologyCerebral Infarction/complicationsCerebral Infarction/pathologyEmbolism/complicationsEndpoint DeterminationFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisProspective StudiesRecurrenceSex FactorsStroke/epidemiology*Stroke/etiologySurvival AnalysisTreatment Outcome
DOI
10.1002/ana.10644
PMID
12891675
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
방, 오영이, 필휴주, 인수허, 균
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