61 194

Cited 0 times in

Immortalization of normal adult human middle ear epithelial cells using a retrovirus containing the E6/E7 genes of human papillomavirus type 16.

Authors
Chun, YM; Moon, SK; Lee, HY; Webster, P; Brackmann, DE; Rhim, JS; Lim, DJ
Citation
The Annals of otology, rhinology, and laryngology, 111(6):507-517, 2002
Journal Title
The Annals of otology, rhinology, and laryngology
ISSN
0003-48941943-572X
Abstract
A human middle ear epithelial cell line (HMEEC-1) was established using human papillomavirus E6/E7 genes. HMEEC-1 has remained morphologically and phenotypically stable, even after 50 passages. The cells are anchorage-dependent and nontumorigenic when injected into nude mice. This cell line thus provides a new tool for the study of normal cell biology and the pathological processes associated with the epithelial cells of the middle ear in otitis media. HMEEC-1 will also be useful in the search for new drugs and biological agents for the treatment of otitis media.
MeSH terms
AdultAnimalsCell LineEar, Middle/*cytologyEpithelial CellsGenetic VectorsHumansMiceMice, NudeOncogene Proteins, Viral/geneticsPapillomaviridae/*geneticsPapillomavirus E7 Proteins*Repressor ProteinsReverse Transcriptase Polymerase Chain Reaction
DOI
10.1177/000348940211100606
PMID
12090706
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
AJOU Authors
문, 성균
Files in This Item:
Full-Text Not Available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse