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Induction of homosynaptic long-term depression in entorhinal cortex.

Authors
Cheong, MY; Yun, SH; Mook-Jung, I; Kang, Y; Jung, MW
Citation
Brain research, 954(2):308-310, 2002
Journal Title
Brain research
ISSN
0006-89931872-6240
Abstract
Prolonged low frequency stimulation (1 Hz, 15 min) induced significant long-term depression (LTD) in hippocampal CA1 region and superficial, but not deep, layers of rat medial entorhinal cortex (EC) in vitro. In the presence of D-AP5, significant LTD was induced in EC superficial layers, but not in CA1 or EC deep layers. These results show differences in characteristics of LTD induction across CA1, EC superficial layers, and EC deep layers.
MeSH terms
2-Amino-5-phosphonovalerate/pharmacologyAnimalsElectrophysiologyEntorhinal Cortex/drug effects/metabolism/*physiologyExcitatory Amino Acid Antagonists/pharmacologyExcitatory Postsynaptic Potentials/drug effectsHippocampus/physiology*Long-Term Synaptic Depression/drug effectsMaleNeuronal Plasticity/drug effects/physiologyRatsRats, Sprague-DawleyReceptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*metabolism*Synaptic Transmission/drug effects
PMID
12414114
Appears in Collections:
Journal Papers > Research Organization > Brain Disease Research Center
Journal Papers > Research Organization > Institute for Medical Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
묵, 인희강, 엽정, 민환
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