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Protein kinase C inhibitors attenuate protective effect of high glucose against hypoxic injury in H9c2 cardiac cells.

Authors
Moon, CH; Jung, YS; Kim, MH; Park, RM; Lee, SH; Baik, EJ
Citation
The Japanese journal of physiology, 50(6):645-649, 2000
Journal Title
The Japanese journal of physiology
ISSN
0021-521X1881-1396
Abstract
In this study, we demonstrated that PKC inhibitors significantly attenuated the cardioprotective effect produced by high-glucose (22 mM) treatment for 48 h against hypoxic injury in H9c2 cardiac cells. PKC activators mimicked the cardioprotective effect of high glucose. These results suggest a possible role of PKC activation in high-glucose--induced protection.
MeSH terms
AnimalsCell Hypoxia/*drug effectsCell LineDrug AntagonismEnzyme Inhibitors/*pharmacologyGlucose/*pharmacologyHumansMyocardium/metabolism/*pathologyProtein Kinase C/*antagonists & inhibitors
PMID
11173560
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
문, 창현정, 이숙이, 수환백, 은주
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