Protein kinase C inhibitors attenuate protective effect of high glucose against hypoxic injury in H9c2 cardiac cells.
Moon, CH; Jung, YS; Kim, MH; Park, RM; Lee, SH; Baik, EJ
The Japanese journal of physiology, 50(6):645-649, 2000
The Japanese journal of physiology
In this study, we demonstrated that PKC inhibitors significantly attenuated the cardioprotective effect produced by high-glucose (22 mM) treatment for 48 h against hypoxic injury in H9c2 cardiac cells. PKC activators mimicked the cardioprotective effect of high glucose. These results suggest a possible role of PKC activation in high-glucose--induced protection.
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