Cited 0 times in Scipus Cited Count

Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice.

DC Field Value Language
dc.contributor.authorMook-Jung, I-
dc.contributor.authorHong, HS-
dc.contributor.authorBoo, JH-
dc.contributor.authorLee, KH-
dc.contributor.authorYun, SH-
dc.contributor.authorCheong, MY-
dc.contributor.authorJoo, I-
dc.contributor.authorHuh, K-
dc.contributor.authorJung, MW-
dc.date.accessioned2011-08-24T05:43:29Z-
dc.date.available2011-08-24T05:43:29Z-
dc.date.issued2001-
dc.identifier.issn0360-4012-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3929-
dc.description.abstractWe investigated the cognition enhancing effects of ginsenoside Rb1 and Rg1. Mice were trained in a Morris water maze following injection (i.p.) of Rb1 (1 mg/kg) or Rg1 (1 mg/kg) for 4 days. Both Rb1- and Rg1-injected mice showed enhanced spatial learning compared to control animals. The hippocampus, but not the frontal cortex, of treated mice contained higher density of a synaptic marker protein, synaptophysin, compared to control mice. Electrophysiological recordings in hippocampal slices revealed that Rb1 or Rg1 injection did not change the magnitude of paired-pulse facilitation or long-term potentiation. Our results suggest that Rb1 and Rg1 enhance spatial learning ability by increasing hippocampal synaptic density without changing plasticity of individual synapses.-
dc.formatapplication/pdf-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHCentral Nervous System Agents-
dc.subject.MESHCognition-
dc.subject.MESHElectrophysiology-
dc.subject.MESHGinsenosides-
dc.subject.MESHHippocampus-
dc.subject.MESHLong-Term Potentiation-
dc.subject.MESHMaze Learning-
dc.subject.MESHMemory-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHSaponins-
dc.subject.MESHSpace Perception-
dc.subject.MESHSynapses-
dc.subject.MESHSynaptophysin-
dc.titleGinsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice.-
dc.typeArticle-
dc.identifier.pmid11241586-
dc.contributor.affiliatedAuthor묵, 인희-
dc.contributor.affiliatedAuthor주, 인수-
dc.contributor.affiliatedAuthor허, 균-
dc.contributor.affiliatedAuthor정, 민환-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/jnr.1045-
dc.citation.titleJournal of neuroscience research-
dc.citation.volume63-
dc.citation.number6-
dc.citation.date2001-
dc.citation.startPage509-
dc.citation.endPage515-
dc.identifier.bibliographicCitationJournal of neuroscience research, 63(6). : 509-515, 2001-
dc.identifier.eissn1097-4547-
dc.relation.journalidJ003604012-
Appears in Collections:
Journal Papers > Research Organization > Brain Disease Research Center
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Humanities & Social Medicine
Journal Papers > Research Organization > Institute for Medical Sciences
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse