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Lipopolysaccharide inhibits induction of long-term potentiation and depression in the rat hippocampal CA1 area.

Jo, JH; Park, EJ; Lee, JK; Jung, MW; Lee, CJ
European journal of pharmacology, 422(1-3):69-76, 2001
Journal Title
European journal of pharmacology
We examined the effects of lipopolysaccharide, a bacterial endotoxin, on synaptic plasticity in the rat hippocampal CA1 area in vitro. Lipopolysaccharide suppressed the induction of long-term potentiation elicited by tetanic stimulation and long-term depression, elicited by low-frequency stimulation of Schaffer collateral-commissural fibres at 10 and 50 microg/ml, respectively. Lipid A (1 microg/ml), the biologically active component of lipopolysaccharide, mimicked the effects of 10 microg/ml lipopolysaccharide on long-term potentiation and depression. Nifedipine, an L-type voltage-sensitive Ca(2+) channel antagonist, did not influence the induction of long-term potentiation and depression, whereas a high concentration of extracellular calcium enabled long-term potentiation induction in the presence of 10 microg/ml lipopolysaccharide. The NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid (APV, 50 microM), nifedipine (10 microM) or lipopolysaccharide (10 or 50 microg/ml) partially reduced the magnitude of tetraethylammonium-induced long-term potentiation. Nifedipine combined with lipopolysaccharide completely blocked tetraethylammonium-induced long-term potentiation. Whole-cell voltage clamp recordings showed that lipopolysaccharide suppressed NMDA receptor-mediated excitatory postsynaptic currents (EPSCs). Our results indicate that lipopolysaccharide acutely modifies synaptic plasticity by blocking Ca(2+) entry through NMDA receptors, suggesting a possible mechanism for the amnesic action of bacterial infection.
MeSH terms
AnimalsCalcium/pharmacologyCalcium Channel Blockers/pharmacologyExcitatory Postsynaptic Potentials/drug effectsHippocampus/drug effects*Hippocampus/physiologyLipopolysaccharides/pharmacology*Long-Term Potentiation/drug effects*Neuronal Plasticity/drug effectsNifedipine/pharmacologyRatsRats, Sprague-DawleyReceptors, N-Methyl-D-Aspartate/physiologySynapses/drug effectsTime Factors
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Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
정, 민환
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