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Neuroprotective effects of estrogen against beta-amyloid toxicity are mediated by estrogen receptors in cultured neuronal cells.

Authors
Kim, H; Bang, OY; Jung, MW; Ha, SD; Hong, HS; Huh, K; Kim, SU; Mook-Jung, I
Citation
Neuroscience letters, 302(1):58-62, 2001
Journal Title
Neuroscience letters
ISSN
0304-39401872-7972
Abstract
Although estrogen is known to exert beneficial effects on Alzheimer's disease, its underlying cellular mechanisms have not been clear. In this study we investigated whether or not neuroprotective effects of estrogen are mediated by estrogen receptors (ERs). Treatment of estrogen (1.8 nM) reduced beta-amyloid (Abeta)-induced death of ER-expressing W4 cells. This effect of estrogen was blocked by a specific ER blocker ICI 182,780. When estrogen was treated to HT22 cells, which lack functional ERs, Abeta-induced cell death was not affected. Transfection of HT22 cells with human ERalpha, but not ERbeta, restored protective action of estrogen against Abeta. Hoechst staining revealed that estrogen protected ERalpha-expressing cells by blocking Abeta-induced apoptosis. These results indicate that estrogen blocks Abeta-induced cell death via ERalpha-dependent pathways.
MeSH terms
Amyloid beta-Peptides/antagonists & inhibitors*Amyloid beta-Peptides/pharmacologyApoptosis/drug effects*Apoptosis/physiologyCell Death/drug effectsCell Death/physiologyCells, CulturedEstradiol/analogs & derivatives*Estradiol/pharmacologyEstrogen Antagonists/pharmacologyEstrogen Receptor alphaEstrogen Receptor betaEstrogens/pharmacology*HumansNeurons/drug effects*Neurons/metabolismReceptors, Estrogen/drug effects*Receptors, Estrogen/metabolismTransfection
PMID
11278111
Appears in Collections:
Journal Papers > Research Organization > Brain Disease Research Center
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
방, 오영정, 민환허, 균김, 승업묵, 인희
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