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A novel disintegrin salmosin inhibits tumor angiogenesis.

Authors
Kang, IC; Lee, YD; Kim, DS
Citation
Cancer research, 59(15):3754-3760, 1999
Journal Title
Cancer research
ISSN
0008-54721538-7445
Abstract
Salmosin is a snake venom-derived novel disintegrin that antagonizes platelet aggregation. In this study, we investigated its functional specificity in tumor angiogenesis. Salmosin significantly inhibited bovine capillary endothelial cell proliferation induced by basic fibroblast growth factor but had no effect on normal growth of the cell. The basic fibroblast growth factor-induced in vivo angiogenesis in the chorioallantoic membrane was disrupted by salmosin treatment without affecting normal embryonic angiogenesis. Adhesion of the bovine capillary endothelial cells to vitronectin was also inhibited by the binding of salmosin to the alpha(v)beta3 integrin. Both the metastatic-tumor growth and the solid-tumor growth that developed in mice were effectively suppressed by salmosin treatment. Several lines of experimental evidence strongly suggest that the tumor-specific antiangiogenic activity of salmosin disrupts tumor growth by blocking the alpha(v)beta3 integrin that is expressed on the vascular endothelial cell surface.
MeSH terms
Allantois/blood supplyAllantois/drug effectsAnimalsAntineoplastic Agents/pharmacology*Antineoplastic Agents/therapeutic useCarcinoma/pathologyCarcinoma/prevention & controlCarcinoma/secondaryCattleCell Adhesion/drug effectsCells, CulturedChick EmbryoChorion/blood supplyChorion/drug effectsCrotalid Venoms/pharmacology*Crotalid Venoms/therapeutic useEndothelium, Vascular/cytologyFibroblast Growth Factor 2/antagonists & inhibitorsFibroblast Growth Factor 2/pharmacologyLung Neoplasms/pathologyLung Neoplasms/prevention & controlLung Neoplasms/secondaryMiceMice, Inbred C57BLNeoplasm Proteins/antagonists & inhibitorsNeoplasm TransplantationNeovascularization, Pathologic/drug therapy*OligopeptidesReceptors, Vitronectin/antagonists & inhibitorsTumor Cells, Cultured/drug effectsTumor Cells, Cultured/transplantationVitronectin/metabolism
PMID
10446992
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
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이, 영돈
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