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Overexpression of c-ErbB-2 protein in gastric cancer by immunohistochemical stain.

Authors
Lee, HR; Kim, JH; Uhm, HD; Ahn, JB; Rha, SY; Cho, JY; Lee, JI; Lee, KH; Chung, HC; Roh, JK; Min, JS; Lee, KS; Shin, DH; Kim, BS; Hong, SW; Choi, JH
Citation
Oncology, 53(3):192-197, 1996
Journal Title
Oncology
ISSN
0030-24141423-0232
Abstract
An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.
MeSH terms
AdultAgedFemaleHumansImmunohistochemistryMaleMiddle AgedPrognosisReceptor, erbB-2/*analysisStomach Neoplasms/*chemistry/pathology/surgerySurvival Analysis
PMID
8643220
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
AJOU Authors
최, 진혁
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