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Dopaminergic influences on the P300 abnormality in Parkinson's disease.

Sohn, YH; Kim, GW; Huh, K; Kim, JS
Journal of the neurological sciences, 158(1):83-87, 1998
Journal Title
Journal of the neurological sciences
This study was designed to evaluate the contribution of central dopaminergic mechanisms to the P300 event-related potential (P300) abnormality in Parkinson's disease. We measured the P300 in 37 non-demented patients with Parkinson's disease (19 de novo and 18 levodopa-treated) and 15 age-matched healthy volunteers. The P300 measurement was repeated in 14 de novo patients, after 6-12 months levodopa therapy. The severity of parkinsonian symptom was assessed using the UPDRS-motor scale. De novo patients showed prolonged P300 latency compared with levodopa-treated patients, as well as healthy volunteers. The levodopa therapy for 6-12 months significantly shortened the P300 latency and reduced the UPDRS-motor examination score in de novo patients. However, the percent changes in the P300 latency were not correlated with those in the UPDRS-motor examination score. These results indicate that the central dopaminergic mechanisms apart from those responsible for motor symptoms, may contribute to the P300 abnormality in Parkinson's disease.
MeSH terms
Acoustic StimulationAgedAntiparkinson Agents/administration & dosage/*pharmacology/therapeutic useCholinergic Antagonists/administration & dosage/pharmacology/therapeutic useCognition Disorders/drug therapy/etiology/*physiopathologyDopamine/*physiologyDopamine Agonists/administration & dosage/*pharmacology/therapeutic useDrug Therapy, CombinationElectroencephalography/*drug effects*Event-Related Potentials, P300FemaleHumansLevodopa/administration & dosage/*pharmacology/therapeutic useLongitudinal StudiesMaleMental ProcessesMiddle AgedParkinson Disease/complications/drug therapy/*physiopathology/psychologyReaction Time/drug effectsSeverity of Illness Index
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Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
허, 균김, 장성
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