126 430

Cited 0 times in

Cyproheptadine augmentation of haloperidol in chronic schizophrenic patients: a double-blind placebo-controlled study.

DC Field Value Language
dc.contributor.authorLee, HS-
dc.contributor.authorSong, DH-
dc.contributor.authorKim, JH-
dc.contributor.authorLee, YM-
dc.contributor.authorHan, ES-
dc.contributor.authorYoo, KJ-
dc.date.accessioned2011-09-08T01:32:39Z-
dc.date.available2011-09-08T01:32:39Z-
dc.date.issued1995-
dc.identifier.issn0268-1315-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4093-
dc.description.abstractA 6 week double-blind placebo-controlled trial of cyproheptadine augmentation of ongoing haloperidol treatment was conducted in 40 chronic schizophrenic in-patients. Cyproheptadine augmentation, compared to administration of haloperidol with placebo, did not produce a statistically significant improvement in psychotic symptoms. Cyproheptadine augmentation caused significant reduction in the extrapyramidal symptoms, which supports the atypical profile of antipsychotics. As to the neuroendocrinological effect, cyproheptadine augmentation did not reduce the plasma prolactin level but did induce a decrease in the plasma cortisol level. Although long-term follow-up studies are needed to confirm the results, this study suggests that cyproheptadine augmentation may be effective in treating chronic schizophrenic patients who are intolerant of extrapyramidal side effects of conventional antipsychotics.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHChronic Disease-
dc.subject.MESHCyproheptadine/*therapeutic use-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHaloperidol/*therapeutic use-
dc.subject.MESHHumans-
dc.subject.MESHHydrocortisone/blood-
dc.subject.MESHMale-
dc.subject.MESHPlacebos-
dc.subject.MESHProlactin/blood-
dc.subject.MESHSchizophrenia/blood/*drug therapy-
dc.subject.MESHTime Factors-
dc.titleCyproheptadine augmentation of haloperidol in chronic schizophrenic patients: a double-blind placebo-controlled study.-
dc.typeArticle-
dc.identifier.pmid7673658-
dc.contributor.affiliatedAuthor이, 영문-
dc.type.localJournal Papers-
dc.citation.titleInternational clinical psychopharmacology-
dc.citation.volume10-
dc.citation.number2-
dc.citation.date1995-
dc.citation.startPage67-
dc.citation.endPage72-
dc.identifier.bibliographicCitationInternational clinical psychopharmacology, 10(2):67-72, 1995-
dc.identifier.eissn1473-5857-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Humanities & Social Medicine
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse