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Attenuation of oxidative neuronal necrosis by a dopamine D1 agonist in mouse cortical cell cultures.

Authors
Noh, JS; Gwag, BJ
Citation
Experimental neurology, 146(2):604-608, 1997
Journal Title
Experimental neurology
ISSN
0014-48861090-2430
Abstract
Events which lead to an increase in intracellular free radicals induce necrotic cell death of cultured cortical neurons. In the present study, we report that treatment with 1 microM (+/-)-SKF-38393 hydrochloride, a selective D1 agonist, as well as 100 microM trolox, a lipophilic vitamin E analogue, significantly prevented oxidative-related necrotic cell death following exposure to 10 microM Fe2+ or 1 mM buthionine sulfoximine, an inhibitor of gamma-glutamylcysteine synthetase. The neuroprotective effect of (+/-)-SKF-38393 hydrochloride was partially reversed by addition of (+/-)-SKF-83566 hydrochloride, a selective D1 antagonist. Quinelorane dihydrochloride, a selective D2 agonist, did not influence free radical neurotoxicity. Interestingly, inclusion of (+/-)-SKF-38393 hydrochloride or quinelorane dihydrochloride did not attenuate apoptotic cell death of cortical neurons deprived of serum. The present study provides evidence that (+/-)-SKF-38393 hydrochloride attenuates oxidative neuronal necrosis, which has unique therapeutic potential for the treatment of various neurodegenerative diseases linked to oxidative stress.
MeSH terms
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/analogs & derivatives/*pharmacologyAnimalsAntioxidants/pharmacologyApoptosisCells, CulturedCerebral Cortex/drug effects/*metabolism/*pathologyChromans/pharmacologyCulture Media, Serum-Free/pharmacologyDopamine Agonists/*pharmacologyDopamine Antagonists/pharmacologyMice/embryologyNecrosisNeurons/*drug effects/*pathologyNeuroprotective Agents/*pharmacologyOxidation-ReductionReceptors, Dopamine D1/*agonistsVitamin E/analogs & derivatives
DOI
10.1006/exnr.1997.6569
PMID
9270075
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
AJOU Authors
노, 재성곽, 병주
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