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Tc-99m MIBI SPECT is useful for noninvasively predicting the presence of MDR1 gene-encoded P-glycoprotein in patients with hepatocellular carcinoma.

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dc.contributor.authorKim, YS-
dc.contributor.authorCho, SW-
dc.contributor.authorLee, KJ-
dc.contributor.authorHahm, KB-
dc.contributor.authorWang, HJ-
dc.contributor.authorYim, H-
dc.contributor.authorJin, YM-
dc.contributor.authorPark, CH-
dc.date.accessioned2011-09-16T04:50:47Z-
dc.date.available2011-09-16T04:50:47Z-
dc.date.issued1999-
dc.identifier.issn0363-9762-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4190-
dc.description.abstractPURPOSE: Resistance to chemotherapeutic drugs continues to be one of the major unsolved problems in the treatment of cancer. Multidrug resistance is defined as the ability of cells exposed to a single drug to develop resistance to a broad range of structurally and functionally unrelated drugs as a result of enhanced outward transport of drugs mediated by P-glycoprotein that is encoded by multidrug resistance genes. Recent evidence has shown that Tc-99m MIBI is a suitable transport substrate for P-glycoprotein. A potential advantage of Tc-99m MIBI SPECT is its superiority to diagnose noninvasively the presence of P-glycoprotein overexpression in vivo. In this study, the authors determined the association of enhanced MIBI efflux in Tc-99m MIBI SPECT with overexpression of P-glycoprotein in hepatocellular carcinoma.
MATERIALS AND METHODS: Thirty-five patients with hepatocellular carcinoma were enrolled in the study. Tc-99m MIBI SPECT was performed 10 minutes after intravenous injection of 20 mCi Tc-99m MIBI. All patients had liver biopsy or surgery within 1 week of MIBI imaging. Immunohistochemical study of the biopsy or resected hepatocellular carcinoma specimens was performed using the avidin-biotin-peroxidase technique with monoclonal antibody JSB-1 directed against P-glycoprotein.
RESULTS: On Tc-99m MIBI SPECT, 30 of 35 (85.7%) patients with hepatocellular carcinoma had no Tc-99m MIBI uptake in tumor lesions, whereas five patients with hepatocellular carcinoma had Tc-99m MIBI uptake in tumor lesions. P-glycoprotein expression was observed in tumor tissues of all the patients without Tc-99m MIBI uptake, whereas among the five patients with Tc-99m MIBI uptake, no P-glycoprotein expression was seen in tumor lesions (P < 0.015).
CONCLUSION: Tc-99m MIBI SPECT is useful for noninvasively predicting the presence of MDR1 gene-encoded P-glycoprotein in patients with hepatocellular carcinoma.
en
dc.language.isoen-
dc.subject.MESHCarcinoma, Hepatocellular-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHGenes, MDR-
dc.subject.MESHHumans-
dc.subject.MESHImmunoenzyme Techniques-
dc.subject.MESHLiver-
dc.subject.MESHLiver Neoplasms-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHP-Glycoprotein-
dc.subject.MESHRadiopharmaceuticals-
dc.subject.MESHTechnetium Tc 99m Sestamibi-
dc.subject.MESHTomography, Emission-Computed, Single-Photon-
dc.titleTc-99m MIBI SPECT is useful for noninvasively predicting the presence of MDR1 gene-encoded P-glycoprotein in patients with hepatocellular carcinoma.-
dc.typeArticle-
dc.identifier.pmid10551471-
dc.contributor.affiliatedAuthor김, 영수-
dc.contributor.affiliatedAuthor조, 성원-
dc.contributor.affiliatedAuthor이, 광재-
dc.contributor.affiliatedAuthor함, 기백-
dc.contributor.affiliatedAuthor왕, 희정-
dc.contributor.affiliatedAuthor임, 현이-
dc.contributor.affiliatedAuthor진, 윤미-
dc.contributor.affiliatedAuthor박, 찬희-
dc.type.localJournal Papers-
dc.identifier.doi10.1097/00003072-199911000-00011-
dc.citation.titleClinical nuclear medicine-
dc.citation.volume24-
dc.citation.number11-
dc.citation.date1999-
dc.citation.startPage874-
dc.citation.endPage879-
dc.identifier.bibliographicCitationClinical nuclear medicine, 24(11). : 874-879, 1999-
dc.identifier.eissn1536-0229-
dc.relation.journalidJ003639762-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
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