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Significance of Erythrocyte Sedimentation Rate and C-reactive Protein as Predictive Factors for Prognosis in Non-metastatic Renal Cell Carcinoma

Other Title
비전이성 신세포암의 예후 예측인자로서 적혈구침강속도와 C반응단백의 의의
Authors
김, 영균; 김, 선일; 김, 세중
Citation
Taehan Pinyogikwa Hakhoe chi, 47(10):1059-1064, 2006
Journal Title
Taehan Pinyogikwa Hakhoe chi; The Korean journal of urology; 대한비뇨기과학회지
ISSN
0494-4747
Abstract
Purpose: This study was performed to investigate the significance of preoperative erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) and postoperative ESR and CRP nadir as predictive factors for prognosis in patients with non-metastatic renal cell carcinoma(RCC).



Materials & Methods: In 66 patients with non-metastatic RCC for whom ESR and CRP could be measured before radical nephrectomy and during follow-up, the preoperative ESR, preoperative CRP, postoperative ESR nadir and postoperative CRP nadir were compared with the clinicopathological variables.



Results: Patients with elevated preoperative ESR or CRP levels were more likely to have tumors with adverse features, including larger tumor size, higher T stage, higher nuclear grade and more frequent metastasis at follow-up, as compared to those patients with lower preoperative ESR or CRP levels, respectively. Patients with an elevated postoperative CRP nadir developed metastasis more frequently at follow-up as compared to those patients with a lower level of postoperative CRP nadir. The univariate analyses identified tumor size, T stage, preoperative ESR, preoperative CRP and postoperative CRP nadir as significant prognostic factors for recurrence-free survival



Conclusion: Elevated preoperative ESR, preoperative CRP and postoperative CRP nadir are associated with a worse prognosis and a higher recurrence rate in patients with non-metastatic RCC, suggesting that ESR and CRP are valuable prognostic indicators in RCC.
Keywords
Renal cell carcinomaErythrocyte sedimentation rateC- reactive proteinPrognosis
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
AJOU Authors
김, 선일김, 세중
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