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Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma

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dc.contributor.author원, 용연-
dc.contributor.author주, 희재-
dc.contributor.author조, 대성-
dc.contributor.author서, 경식-
dc.contributor.author안, 병철-
dc.contributor.author김, 기훈-
dc.contributor.author김, 세중-
dc.date.accessioned2011-11-22-
dc.date.available2011-11-22-
dc.date.issued2006-
dc.identifier.issn0494-4747-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/4494-
dc.description.abstractPurpose: We investigated the relationship between the expression of caveolin-1, using a tissue microarray(TMA), and the prognosis of patients with renal cell carcinoma(RCC).
Materials and Methods: TMA sections of formalin-fixed, paraffin-embedded tissues of RCC from 82 patients, who had undergone radical nephrectomy, were stained immunohistochemically with specific antibodies against caveolin-1. The caveolin-1 immunostaining was semi-quantitatively estimated based on intensity. The expression pattern of caveolin-1 was compared with the clinicopathological variables.
Results: The expression of caveolin-1 was significantly correlated with tumor size(p=0.002), TNM stage(p<0.001), T stage(p=0.001), M stage (p=0.004), grade(p=0.028) and metastasis(p<0.001), and was also significantly higher in clear cell than non-clear cell RCC(p<0.001). The survival of patients with higher caveolin-1 expression was significantly worse than that of patients with lower caveolin-1 expression(p=0.001). Univariate analyses were able to identify all variables, including caveolin-1 expression as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that TNM stage, M stage and grade were independent prognostic factors. Caveolin-1 expression was not an independent factor.
Conclusions: The increased expression of caveolin-1 is associated with tumor size, stage, grade, metastasis and a worse prognosis in RCC, which suggests that caveolin-1 may be important in the progression of RCC.
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dc.formattext/plain-
dc.language.isoko-
dc.titleCorrelation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma-
dc.title.alternative신세포암에서 Tissue Microarray를 이용하여 분석한 Caveolin-1 발현과 예후와의 연관성-
dc.typeArticle-
dc.identifier.urlhttp://pdf.medrang.co.kr/Kju/047/Kju047-06-08.pdf-
dc.subject.keywordCaveolin-1-
dc.subject.keywordTissue microarray-
dc.subject.keywordPrognosis-
dc.subject.keywordRenal cell carcinoma-
dc.contributor.affiliatedAuthor원, 용연-
dc.contributor.affiliatedAuthor주, 희재-
dc.contributor.affiliatedAuthor조, 대성-
dc.contributor.affiliatedAuthor안, 병철-
dc.contributor.affiliatedAuthor김, 세중-
dc.type.localJournal Papers-
dc.identifier.doi10.4111/kju.2006.47.6.607-
dc.citation.titleKorean journal of urology-
dc.citation.volume47-
dc.citation.number6-
dc.citation.date2006-
dc.citation.startPage607-
dc.citation.endPage613-
dc.identifier.bibliographicCitationKorean journal of urology, 47(6). : 607-613, 2006-
dc.relation.journalidJ004944747-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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