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Effect of Anti-idiotype Antibody on Anti-DNA Antibody Production by Hybridoma Cells

Other Title
항이디오타입 항체가 하이브리도마 세포의 항DNA 항체 생산에 미치는 영향
박, 선 | 김, 형일 | 이, 미리나 | 김, 영태 | 윤, 정구 | 김, 주덕
Korean journal of immunology, 19(4). : 513-524, 1997
Journal Title
Korean journal of immunology
Anti-idiotype antibody (anti-id Ab) which recognizes idiotope in the variable region of immunoglobulin (Ig) can regulate Ab production by B cells in vivo and in vitro.

Although it has been reported that anti-id Ab can suppress IgM production by

lymphocytes or hybridoma cells without suppression of cell proliferation, the regulatory mechanism of anti-id Ab is not completely understood.

We studied the effects of anti-id Ab on the production of IgG class anti-DNA Ab by

hybridoma cells, on the proliferation of cells, and on the transcription levels of Ig genes.

In contrast to suppressive effect of anti-id Ab on the production of IgM previously

reported by others, stimulatory effects of anti-id Ab on the production of IgG by

hybridoma cells as well as the proliferation of these cells were observed. However, little effect of anti-id Ab on the transcription levels of Ig genes was observed.

These results suggest that anti-id Ab can increase Ab production by stimulation of

cell proliferation. Furthermore, these results suggest that the effect of anti-id Ab on the

production of Ab may be determined by the difference in class of Ab produced by

hybridoma cells following the treatment with anti-id Ab.

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Journal Papers > School of Medicine / Graduate School of Medicine > Unclassified
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