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Effect of Anti-idiotype Antibody on Anti-DNA Antibody Production by Hybridoma Cells

Other Title
항이디오타입 항체가 하이브리도마 세포의 항DNA 항체 생산에 미치는 영향
박, 선; 김, 형일; 이, 미리나; 김, 영태; 윤, 정구; 김, 주덕
Taehan Myŏnyŏk Hakhoe chi, 19(4):513-524, 1997
Journal Title
Taehan Myŏnyŏk Hakhoe chi; The Korean journal of immunology : official journal of the Korean Society for Immunology; 대한면역학회지
Anti-idiotype antibody (anti-id Ab) which recognizes idiotope in the variable region of immunoglobulin (Ig) can regulate Ab production by B cells in vivo and in vitro.

Although it has been reported that anti-id Ab can suppress IgM production by

lymphocytes or hybridoma cells without suppression of cell proliferation, the regulatory mechanism of anti-id Ab is not completely understood.

We studied the effects of anti-id Ab on the production of IgG class anti-DNA Ab by

hybridoma cells, on the proliferation of cells, and on the transcription levels of Ig genes.

In contrast to suppressive effect of anti-id Ab on the production of IgM previously

reported by others, stimulatory effects of anti-id Ab on the production of IgG by

hybridoma cells as well as the proliferation of these cells were observed. However, little effect of anti-id Ab on the transcription levels of Ig genes was observed.

These results suggest that anti-id Ab can increase Ab production by stimulation of

cell proliferation. Furthermore, these results suggest that the effect of anti-id Ab on the

production of Ab may be determined by the difference in class of Ab produced by

hybridoma cells following the treatment with anti-id Ab.
Anti-idiotype antibodyIsotypeAb production
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Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
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