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Studies on Ly-1+B Cells in Autoimmune-prone Strain of MRL/lpr Mice

Jang, YJ  | Youn, JK  | Park, JS | Kim, YT
Ajou medical journal, 2(1). : 40-45, 1997
Journal Title
Ajou medical journal
Ly-1 antigen is a surface antigen of murine T cells and is also expressed on the membrane of certain B cell population, especially the B cells in the peritoneal cavity of mice. Ly-1 antigen is the same molecule of CD5 antigen expressed on human T cells and a certain population of human B cells. It is suggested that Ly-l^(+)B cells are possibly involved in the pathogenesis of autoimmune diseases. In the present work, we analysed the profiles of the distribution of Ly-1^(+)B cells in the autoimmune-prone strain of MRL/1pr mice with different ages and normal mice (BALB/c and C57BL/6), because most of the studies for exploring the role of Ly-1^(+)B cells in the pathogenesis of autoimmune diseases have been carried out by using autoimmune-prone NZB-related mice. Two-parameter FACS analysis was used to investigate the percentage of Ly-1^(+)B cell subpopulation in spleens and peritoneal cavities of normal mice and autoimmune-prone MRL/1pr mice with different ages. It is shown that Ly-1^(+)B cell subpopulations in spleens and peritoneal cavities are present in increased number in MRL/lpr mice, suggesting an important role of Ly-1^(+)B cells in autoimmunity. In addition, older MRL/lpr mice showed higher number of Ly-1^(+)B cells as compared with those of young MRL/1pr mice.

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Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Ajou Authors
윤, 정구  |  장, 영주
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