Taehan Sinkyŏng Oekwa Hakhoe chi; Journal of Korean Neurosurgical Society; 대한신경외과학회지
Objective：A prospective biochemical assay of prostaglandin E2 content in symptomatic lumbar disc materials was done in order to clarify the pathogenesis of lumbar radiculopathy.
Patients and Methods：Forty-eight disc specimens were purified by a standard solid-phase extraction procedure and analyzed by an enzymelinked immunosorbent assay for prostaglandin E2. Clinical and anatomic correlations were evaluated with analysis of variance and t-test.
Results：Acute herniated lumbar disc diseases tended to be associated with a higher prostaglandin E2 content than degenerative lumbar disc disease. Sequestered discs tended to be associated with a higher prostaglandin E2 content than extruded discs, which also showed higher prostaglandin E2 content than protruded ones. A sciatica and positive straight leg raising test appeared to be associated with a higher prostaglandin E2 content than a negative test.
Conclusion：This result suggests that the level of prostaglandin E2 would be correlated with clinical symptom and sign in the inflammatory process of lumbar disc herniation.
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