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Role of Serum Hepatocyte Growth Factor in Gastric Cancer Patients

Other Title
위암 환자에서 혈청 간세포 성장인자의 역할
Authors
한, 상욱; 김, 욱환; 조, 용관; 김, 명욱; 이, 재호; 김, 현수
Citation
Taehan Oekwa Hakhoe, 56(5):691-700, 1999
Journal Title
Taehan Oekwa Hakhoe; 대한외과학회지
ISSN
1226-0053
Abstract
Background : Hepatocyte growth factor (HGF) was first identified as a potent

stimulator of hepatocyte growth. Later, it was shown that HGF and promote cell

motility and cell proliferation in tumor cells as well as in endothelial cells. To look for

the significance of HGF in patients with gastric cancer, we measured the serum levels

of HGF in gastric cancer patients and followed the levels of HGF after resection of the

tumors.

Methods : The serum levels of HGF were determined by using an Immunis HGF

ELISA kit. The serum levels of CEA, CA125, and CA19-9 in the same serum sample

were examined using the ELISA method.

Results : The mean levels of serum HGF in 212 healthy control subjects, 105 patients

with primary gastric cancer, 54 patients after resections of the tumors, and 13 patients

with recurrent gastric cancer were 0.20±0.07 ng/ml, 0.33±0.26 ng/ml, 0.20±0.19 ng/ml,

and 0.58±0.26 ng/ml respectively. Of the 105 patients with primary gastric cancer, 35

(33.3%) showed an abnormal increase in the serum level of HGF. The increased HGF

levels were significantly associated with the degree of tumor invasion, nodal metastasis,

distant metastasis and stage. Also the HGF levels increased significantly with increasing

tumor size. The HGF levels decreased to normal levels by one month after the

resections of the tumors. The HGF levels in recurrent gastric cancer patients were

significantly higher than those of nonrecurrent patients after resections of the tumors.

Among several tumor markers including CEA, CA125, and CA19-9, HGF was revealed

to be the one most correlated with the occurrence of gastric cancer.

Conclusions : The serum levels of HGF were significantly correlated with the

aggressiveness of the tumors, suggesting that HGF might play an important role in the

tumor progression of gastric cancer. Furthermore, serum HGF levels should be studied

as a tumor marker in patients with gastric cancer.
Keywords
Hepatocyte growth factorTumor markerCEACA125CA19-9Gastric carcinoma
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Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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